Association of lipoprotein-associated phospholipase A2 mass and activity with calcified coronary plaque in young adults -: The CARDIA study
Association of lipoprotein-associated phospholipase A2 mass and activity with calcified coronary plaque in young adults -: The CARDIA study
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DOI：
10.1161/01.atv.0000148322.89911.44
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发表时间：
2005-01-01
影响因子：
8.7
通讯作者：
Loria, CM
中科院分区：
文献类型：
--
作者：
Iribarren, C;Gross, MD;Loria, CM
目的：研究青年人中脂蛋白相关磷脂酶A(2) （Lp-PLA(2)）的质量和活性与钙化冠状动脉斑块的关系。方法与结果：对CARDIA患者进行巢式病例对照研究（2000 - 2001年，33 - 45岁）。病例（n=266）为有冠状动脉钙化斑块的患者，对照组（n=266）为无冠状动脉钙化斑块的患者，性别和种族比例为1:1。实验组Lp-PLA(2)的质量和活性（296+/-101 ng/mL和36.4+/-12.3 nmol/mL / min）显著高于对照组（267+/-80 ng/mL和32.9+/-11.8 nmol/mL / min）。在年龄调整后的条件logistic回归中，每1个标准差（SD）增量的钙化冠状动脉斑块的优势比（OR）在Lp-PLA(2)质量和活性方面分别为1.40 （95% CI， 1.17至1.67）和1.39 （95% CI， 1.14至1.70）。在调整了包括低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯和c反应蛋白在内的多个协变量后，Lp-PLA(2)质量（OR, 1.28; 95% CI， 1.03至1.60）仍然存在统计学上显著的相关性，但与活性（OR, 1.09; 95% CI， 0.84至1.42）无关。没有证据表明Lp-PLA(2)质量或活性与LDL-C之间的相互作用是钙化冠状动脉斑块的预测因子。结论：在年轻人中存在Lp-PLA(2)团块与钙化冠状动脉斑块的独立关联。因此，Lp-PLA(2)质量可能是亚临床心血管风险的有用标志。
Objective - To examine the association of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and activity with calcified coronary plaque in young adults.Methods and Results - Nested case-control study among CARDIA participants at the year 15 examination (2000 to 2001, 33 to 45 years old). Cases (n=266) were those with and controls (n=266) those without evidence of calcified coronary plaque by computed tomography matched 1:1 on sex and race. Lp-PLA(2) mass and activity were significantly higher in cases (296+/-101 ng/mL and 36.4+/-12.3 nmol/mL per minute) than in controls (267+/-80 ng/mL and 32.9+/-11.8 nmol/mL per minute). In age-adjusted conditional logistic regression, the odds ratio (OR) of calcified coronary plaque per 1 standard deviation (SD) increment was 1.40 (95% CI, 1.17 to 1.67) and 1.39 (95% CI, 1.14 to 1.70) for Lp-PLA(2) mass and activity, respectively. After adjusting for multiple covariates including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and C-reactive protein, a statistically significant association remained for Lp-PLA(2) mass (OR, 1.28; 95% CI, 1.03 to 1.60) but not for activity (OR, 1.09; 95% CI, 0.84 to 1.42). No evidence was found for interaction between Lp-PLA(2) mass or activity with LDL-C as predictors of calcified coronary plaque.Conclusion - An independent association of Lp-PLA(2) mass with calcified coronary plaque existed in young adults. Therefore, Lp-PLA(2) mass may be a useful marker of subclinical cardiovascular risk.