Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients.
Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients.
复制标题
慢性乙型肝炎患者首次肝脏缺失 (hMOF) 与病毒持续存在之间的相关性
DOI：
10.1186/s13578-018-0215-5
复制
发表时间：
2018
影响因子：
7.5
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Chen L;Zhu C;Li F;Wang Y;Bao R;Cao Z;Xiang X;Yan L;Lin L;Zhao G;Xie Q;Bao S;Wang H
慢性乙型肝炎(CHB)是一个发病率和死亡率都很高的全球性健康难题。人类男性第一次缺失(HMOF)(一种组蛋白乙酰转移酶)负责DNA损伤修复、肿瘤发生和细胞周期调节。慢性乙型病毒性肝炎患者中HBVDNA的持续存在与肝硬变和肝细胞癌的发生有关。组蛋白乙酰转移酶可促进乙肝病毒复制，然而hMOF在慢性乙肝患者乙肝病毒复制中的确切潜在机制仍有待探索。本研究旨在探讨慢性乙型肝炎患者肝组织中hMOF与HBVdna复制的关系，为慢性乙型肝炎患者的治疗提供新的思路。方法采用免疫组织化学、定量聚合酶链式反应和免疫印迹法检测慢性乙型肝炎患者肝组织中hMOF，其中HBeAg阳性组33例，−阳性组20例，正常对照组3例。结果CHB患者血清hMOF与HBVdna呈正相关。在HBe Ag阳性的−患者中，hMOF与HBs Ag和/或HBe Ag呈显著正相关，而在HBe Ag和HBs Ag阳性的CHB患者中，hMOF与HBs Ag的相关性不明显。慢性乙型肝炎患者肝组织中hMOF水平与肝组织炎症程度和肝纤维化分期无关。结论肝组织中hMOF可能参与了慢性乙型肝炎患者机体对HBV病毒的清除，并可能参与其发病机制。
BackgroundChronic hepatitis B (CHB) remains a global health dilemma with high morbidity and mortality. Human males absent on the first (hMOF) (a histone acetyltransferase) is responsible for DNA damage repair, tumorigenesis and cell cycle regulation. Persistence of HBV DNA contributes to cirrhosis and hepatocellular carcinoma (HCC) in CHB patients. Histone acetyltransferase enhances HBV replication, however the precise underlying mechanism of hMOF in HBV replication in CHB patients remains to be explored. This study aims to investigate the correlation between hepatic hMOF and HBV DNA replication in CHB patients, and may provide new insights towards the treatment of CHB patients.MethodshMOF in liver biopsy (CHB, n = 33 HBeAg+; n = 20 HBeAg−, and three healthy controls) was determined, using immunohistochemistry, qPCR and Western blot. The correlation between hMOF and HBsAg, as well as, HBeAg were determined.ResultsA positive correlation between hMOF and HBV DNA in overall CHB patients was observed. A distinct positive correlation between hMOF and HBsAg and/or HBeAg in HBeAg+CHB patients was also detected, however not observed between hMOF and HBsAg in HBeAg−CHB patients. No correlation was observed between hMOF and hepatic inflammation severity and fibrotic stage in CHB patients.ConclusionsHepatic hMOF might contribute to host HBV clearance in CHB patients and possible pathogenesis.
登录
查看更多内容
影响因子：
4.6
作者：
Liu Y;Yu F;Han Y;Li Q;Cao Z;Xiang X;Jiang S;Wang X;Lu J;Lai R;Wang H;Cai W;Bao S;Xie Q
通讯作者：
Xie Q
影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
DOI：
10.1186/1756-9966-32-8
发表时间：
2013-02-09
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Wang Y;Zhang R;Wu D;Lu Z;Sun W;Cai Y;Wang C;Jin J
通讯作者：
Jin J
影响因子：
2.3
作者：
Wang Hui-Jun;Chen Huo-Po;Liu Jiping
通讯作者：
Liu Jiping
影响因子：
29.4
作者：
Volz, Tassilo;Lutgehetmann, Marc;Petersen, Joerg
通讯作者：
Petersen, Joerg