Role of Interleukin-10 in Acute Brain Injuries.
Role of Interleukin-10 in Acute Brain Injuries.
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DOI：
10.3389/fneur.2017.00244
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发表时间：
2017
影响因子：
3.4
通讯作者：
Doré S
中科院分区：
文献类型：
--
作者：
Garcia JM;Stillings SA;Leclerc JL;Phillips H;Edwards NJ;Robicsek SA;Hoh BL;Blackburn S;Doré S
白细胞介素-10（IL-10）是响应于脑损伤而表达的重要抗炎细胞因子，其中它促进炎症级联反应的消退，如果延长则引起继发性脑损伤。在这里，我们全面回顾了目前的知识，关于IL-10在调节急性脑损伤，包括创伤性脑损伤（TBI）和各种中风亚型的结果。血管内皮与这些神经系统疾病的病理生理学密切相关，并且研究已经证明IL-10具有明确的血管内皮保护特性。缺血性卒中的体外和体内模型已经令人信服地直接和间接地显示了IL-10介导的神经保护作用;尽管在临床上，IL-10在预测风险和结局中的作用尚不清楚。相比之下，结论性研究调查IL-10在蛛网膜下腔出血的贡献是缺乏的。存在支持IL-10在脑出血临床前模型中的保护作用的弱间接证据;然而，在有限数量的临床研究中，发作后观察到的较高IL-10水平与更差的结局相关。类似地，临床前TBI模型表明IL-10具有神经保护作用;尽管在几项临床研究中存在争议。总之，虽然IL-10在急性脑损伤后持续升高，但IL-10的作用似乎是病理学依赖性的，并且临床前和临床研究通常矛盾地产生相反的结果。IL-10在炎症消退中的显著和有效作用以及文献中关于IL-10在急性脑损伤背景下的作用的不一致性，保证了进一步严格控制和有针对性的研究。
Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged causes secondary brain damage. Here, we comprehensively review the current knowledge regarding the role of IL-10 in modulating outcomes following acute brain injury, including traumatic brain injury (TBI) and the various stroke subtypes. The vascular endothelium is closely tied to the pathophysiology of these neurological disorders and research has demonstrated clear vascular endothelial protective properties for IL-10. In vitro and in vivo models of ischemic stroke have convincingly directly and indirectly shown IL-10-mediated neuroprotection; although clinically, the role of IL-10 in predicting risk and outcomes is less clear. Comparatively, conclusive studies investigating the contribution of IL-10 in subarachnoid hemorrhage are lacking. Weak indirect evidence supporting the protective role of IL-10 in preclinical models of intracerebral hemorrhage exists; however, in the limited number of clinical studies, higher IL-10 levels seen post-ictus have been associated with worse outcomes. Similarly, preclinical TBI models have suggested a neuroprotective role for IL-10; although, controversy exists among the several clinical studies. In summary, while IL-10 is consistently elevated following acute brain injury, the effect of IL-10 appears to be pathology dependent, and preclinical and clinical studies often paradoxically yield opposite results. The pronounced and potent effects of IL-10 in the resolution of inflammation and inconsistency in the literature regarding the contribution of IL-10 in the setting of acute brain injury warrant further rigorously controlled and targeted investigation.