FOXM1 in Cancer: Interactions and Vulnerabilities.
FOXM1 in Cancer: Interactions and Vulnerabilities.
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DOI：
10.1158/0008-5472.can-16-3566
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发表时间：
2017-06-15
期刊：
影响因子：
11.2
通讯作者：
Gartel AL
中科院分区：
文献类型：
--
作者：
Gartel AL
FOXM 1是正常细胞增殖所需的Forkhead家族的转录因子。然而，FOXM 1在多种人类癌症中反复过表达，并且它与Hanahan和温伯格描述的癌症的所有主要标志有关。据推测，FOXM 1的致癌潜力是由其反式激活与癌症发展的不同阶段有关的靶基因的能力决定的。然而，FOXM 1也可能通过与其他蛋白质（如β-连环蛋白或SMAD 3）相互作用，分别诱导致癌WNT和TGF-β信号通路，从而发挥致癌作用。在这篇综述中，我将讨论FOXM 1的蛋白质-蛋白质相互作用，这对癌症的发展至关重要，并可能成为抗癌药物的新靶点。
FOXM1 is a transcription factor of the Forkhead family that is required for cell proliferation of normal cells. However, FOXM1 is repeatedly overexpressed in a variety of human cancers and it has been implicated in all major hallmarks of cancer delineated by Hanahan and Weinberg. It has been postulated that the oncogenic potential of FOXM1 is determined by its capacity to trans-activate target genes that are implicated in different phases of cancer development. However, FOXM1 may also play an oncogenic role by interacting with other proteins such as beta-catenin or SMAD3 to induce oncogeneic WNT and TGF-β signaling pathways, respectively. In this review, I will discuss the protein-protein interactions of FOXM1 that are critical for cancer development and may represent novel targets for anticancer drugs.