Biochemical basis for dose response relationships in reactive metabolite toxicity.
Biochemical basis for dose response relationships in reactive metabolite toxicity.
复制标题
反应性代谢物毒性剂量反应关系的生化基础。
DOI：
10.1007/978-1-4757-0674-1_7
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发表时间：
1981
影响因子：
--
通讯作者：
C. Smith
中科院分区：
文献类型：
--
作者：
D. Jollow;S. Roberts;V. Price;C. Smith
药物和其他外源性物质的大多数药理学和毒理学作用被认为是由化合物与组织受体的可逆组合引起的;作用的程度和持续时间与化合物在靶组织中的浓度-时间曲线成比例。如通常情况，如果组织中的化合物与血浆中的化合物之间存在快速平衡，则化合物的血浆浓度的测定可用作靶组织中化合物的间接测量。在这种情况下，将血药浓度与全身负荷和消除联系起来，从而预测生物效应的严重程度和持续时间的药代动力学方程是众所周知的。
The majority of pharmacological and toxicological effects of drugs and other xenobiotics are believed to result from a reversible combination of the compounds with tissue receptors; the extent and duration of the effects being proportional to the concentration-time profile of the compound in the target tissue. If, as is often the case, there is a rapid equilibrium between compound in tissues and in plasma, determination of the plasma concentrations of the compound can be used as an indirect measure of the compound in the target tissue. The pharmacokinetic equations developed to relate plasma concentrations to total body load and elimination in this situation and thus to predict the severity and duration of the biological effects are well known.