Depressive symptoms and functional transitions over time in older persons.
Depressive symptoms and functional transitions over time in older persons.
复制标题
DOI：
10.1097/jgp.0b013e3181ff6669
复制
发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Gill TM
中科院分区：
文献类型：
--
作者：
Barry LC;Murphy TE;Gill TM
我们确定了临床上显著的抑郁症状（通常称为抑郁症）与随后无残疾、轻度残疾、重度残疾和死亡之间的过渡之间的关联。前瞻性队列研究。一般社区在大纽黑文，康涅狄格州，从1998年3月23日至2008年12月31日。754名70岁或以上的人。每月对日常生活基本活动的残疾进行评估，每18个月使用抑郁症流行病学研究中心量表的简表对抑郁症状进行评估，最长持续129个月。抑郁的参与者比非抑郁的参与者更有可能从无残疾状态过渡到轻度残疾（HR= 1.52; 95% CI 1.25，1.85）和重度残疾（HR=1.57; 95% CI 1.22，2.01），以及从轻度残疾到重度残疾（HR=1.33; 95% CI 1.06，1.65）;从轻度残疾状态转变为无残疾的可能性较小（HR=0.69; 95% CI 0.57，0.85）和从重度残疾状态到无残疾（HR=0.50; 95% CI 0.31，0.79）。抑郁症状与进入和脱离残疾状态的转变有关，并且与从轻度残疾转变为重度残疾的可能性增加有关。更广泛地说，我们的发现强调了抑郁症状和残疾之间关系的复杂性。未来的工作需要评估老年人抑郁症和功能转变之间可能的相互关系。
We determined the association between clinically significant depressive symptoms, often referred to as depression, and subsequent transitions between no disability, mild disability, severe disability, and death. Prospective cohort study. General community in greater New Haven, Connecticut, from March 23, 1998, to December 31, 2008. Seven-hundred fifty four persons, aged 70 years or older. Monthly assessments of disability in essential activities of daily living and assessments of depressive symptoms every 18 months using a short-form of the Center for Epidemiologic Studies of Depression Scale for up to 129 months. Depressed participants were more likely than those who were non-depressed to transition from a state of no disability to mild (HR= 1.52; 95% CI 1.25, 1.85) and severe disability (HR=1.57; 95% CI 1.22, 2.01), and from a state of mild disability to severe disability (HR=1.33; 95% CI 1.06, 1.65); and were less likely to transition from a state of mild disability to no disability (HR=0.69; 95% CI 0.57, 0.85) and from a state of severe disability to no disability (HR=0.50; 95% CI 0.31, 0.79). Depressive symptoms are associated with transitions into and out of disabled states, and with increased likelihood of transitioning from mild to severe disability. More broadly, our findings underscore the complexity of the relationship between depressive symptoms and disability. Future work is needed to evaluate the likely reciprocal relationship between depression and functional transitions in older persons.