Isolated diastolic hypertension is not associated with endothelial dysfunction
Isolated diastolic hypertension is not associated with endothelial dysfunction
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单纯性舒张期高血压与内皮功能障碍无关
DOI：
10.1038/s41440-022-00854-y
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Higashi Y.
中科院分区：
文献类型：
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作者：
Han Y;Maruhashi T;Kajikawa M;Kishimoto S;Yamaji T;Harada T;Hashimoto Y;Yusoff FM;Nakano Y;Chayama K;Nakashima A;Goto C;Yoshimura K;Higashi Y.
高血压与内皮功能受损有关。然而，目前尚不清楚单纯舒张期高血压是否与内皮功能障碍有关。本研究的目的是探讨血管内皮功能与使用两种主要高血压指南诊断的单纯舒张期高血压的关系：根据2017年美国心脏病学会/美国心脏协会高血压指南的收缩压(BP) <； 130 ≥ 和舒张压BP 80 ；根据2018年欧洲心脏病学会/欧洲高血压学会高血压指南的收缩压 <； 140 ≥ 和舒张压 90 mm Hg。我们测量了无收缩期高血压且未接受抗高血压药物治疗的受试者的肱动脉血流介导的血管扩张(FMD)。在3,727名受试者(男性2,813人；平均年龄：41.3ACA10.9岁)中，749人(20.1%)根据2017年 / 定义有单纯舒张期高血压。多因素Logistic回归分析显示，单纯舒张期高血压与内皮功能障碍无关，定义为FMD <； 7.0%(OR，1.15；95%CI，0.98~1.35；P= 0.09)。在4747名受试者中(男性3727名，平均年龄45.1 ±ESH10.8岁)，314名受试者(6.6%)按Esc/ 定义患有单纯舒张期高血压。多因素Logistic回归分析显示，调整年龄和性别后，单纯舒张期高血压与血管内皮功能障碍无关(OR，1.0 4；95%CI，0.82~1.32；P= 0.76)。单独舒张期高血压与未接受抗高血压药物治疗的个体的内皮功能障碍无关，无论使用的主要高血压指南定义如何。
Hypertension is associated with an impairment of endothelial function. However, it is unclear whether isolated diastolic hypertension is associated with endothelial dysfunction. The purpose of this study was to investigate the association of endothelial function with isolated diastolic hypertension diagnosed by using two major hypertension guidelines: systolic blood pressure (BP) < 130 mmHg and diastolic BP ≥ 80 mmHg according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension guideline and systolic BP < 140 mmHg and diastolic BP ≥ 90 mmHg according to the 2018 European Society of Cardiology/European Society of Hypertension (ESC/ESH) hypertension guideline. We measured the flow-mediated vasodilation (FMD) of the brachial artery in subjects without systolic hypertension who were not treated with antihypertensive drugs. Of 3727 subjects (2813 men; mean age: 41.3 ± 10.9 years), 749 (20.1%) had isolated diastolic hypertension according to the 2017 ACC/AHA definition. Multiple logistic regression analysis revealed that isolated diastolic hypertension was not associated with endothelial dysfunction, defined as FMD < 7.0% (OR, 1.15; 95% CI, 0.98–1.35;P= 0.09). Of 4747 subjects (3727 men; mean age: 45.1 ± 10.8 years), 314 subjects (6.6%) had isolated diastolic hypertension according to the ESC/ESH definition. Multiple logistic regression analysis revealed that isolated diastolic hypertension was not associated with endothelial dysfunction after adjusting for age and sex (OR, 1.04; 95% CI, 0.82–1.32;P= 0.76). Isolated diastolic hypertension was not associated with endothelial dysfunction in individuals who were not treated with antihypertensive drugs regardless of the major hypertension guideline definition used.