Effects of dietary fish oil on myocardial ischemic/reperfusion injury of Wistar Kyoto and stroke-prone spontaneously hypertensive rats.
Effects of dietary fish oil on myocardial ischemic/reperfusion injury of Wistar Kyoto and stroke-prone spontaneously hypertensive rats.
复制标题
膳食鱼油对 Wistar京都和脑卒中易发性高血压大鼠心肌缺血/再灌注损伤的影响。
DOI：
10.1016/0026-0495(92)90214-u
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Bowman,J
中科院分区：
文献类型：
--
作者：
Paulson,DJ;Smith,JM;Zhao,J;Bowman,J
本研究的目的是确定15周的膳食鱼油补充剂，以Wistar京都（WKY）和中风倾向的自发性高血压大鼠（SP-SHR）是否会改变心脏收缩性能。离体灌注工作心脏被用来确定不同的左心房充盈压力对心脏泵输出和压力发展的影响。此外，评估了这些心脏在低流量缺血60分钟后再灌注30分钟后恢复心输出量的能力。测定心肌高能磷酸盐水平和长链酰基肉毒碱含量。补充鱼油对WKY大鼠的间接尾袖收缩压没有影响，但对SP-SHR的收缩压有轻微的降低。在不同的左心房充盈压，心脏从WKY大鼠和SP-SHR表现出主动脉血流，左心室内舒张压，收缩压，每单位时间的压力变化率（dP dt），或松弛时间的正和负的差异，但是，冠状动脉血流值在SP-SHR组相对于各自的WKY组较低。补充鱼油对这些心脏参数没有影响。当这些心脏受到缺血和再灌注，心脏收缩性能的恢复在鱼油喂养的WKY和SP-SHR组显着改善，与他们的玉米油喂养的同行相比。上述心脏血流动力学指标的恢复在喂饲玉米油的WKY和SP-SHR之间无差异。这些结果进一步支持了食用鱼油可以显着降低心血管疾病死亡风险的假设。
The purpose of the present study was to determine whether 15 weeks of dietary fish oil supplementation to Wistar Kyoto (WKY) and stroke-prone spontaneously hypertensive rats (SP-SHR) would alter cardiac contractile performance. Isolated perfused working hearts were used to determine the effects of varying left atrial filling pressures on cardiac pump output and pressure development. In addition, the ability of these hearts to recover cardiac output after a 60-minute period of low-flow ischemia followed by 30 minutes of reperfusion was assessed. Myocardial high-energy phosphate levels and long-chain acylcarnitine content were measured. Fish oil supplementation had no effect on indirect tail-cuff systolic blood pressure of WKY rats, but produced a small decrease in systolic blood pressure of SP-SHR. In response to varying left atrial filling pressures, hearts from WKY rats and SP-SHR exhibited no major differences in aortic flow, left intraventricular diastolic pressure, systolic pressure, positive and negative rate of pressure change per unit of time (dP dt), or relaxation time; however, coronary flow values were lower in SP-SHR groups relative to respective WKY groups. Fish oil supplementation had no effect on these cardiac parameters. When these hearts were subjected to ischemia and reperfusion, the recovery of cardiac contractile performance was significantly improved in fish oil-fed WKY and SP-SHR groups, compared with their corn oil-fed counterparts. There were no differences in the recovery of the above cardiac hemodynamic parameters between corn oil-fed WKY and SP-SHR. These results provide further support to the hypothesis that dietary fish oil can significantly reduce the mortality risk from cardiovascular disease.