Association and expression study of synapsin III and schizophrenia.
Association and expression study of synapsin III and schizophrenia.
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DOI：
10.1016/j.neulet.2009.09.032
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发表时间：
2009-11-20
影响因子：
2.5
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Chen Q;Che R;Wang X;O'Neill FA;Walsh D;Tang W;Shi Y;He L;Kendler KS;Chen X
突触蛋白III基因SYN3属于突触囊泡相关蛋白家族，与神经递质释放和突触发生的调节有关，提示在几种神经精神疾病中有潜在作用。人类SYN3基因位于22q12-13染色体上，这是先前精神分裂症连锁研究中涉及的一个候选区域。然而，SYN3与精神分裂症的关联研究产生了不一致的结果。在这项研究中，四个SYN3 snp (rs133945（- 631c>g), rs133946(- 196g>a)， rs9862和rs1056484）在三组共3759个样本中进行了检测，其中包括爱尔兰精神分裂症病例对照研究（ICCSS）中的655名患者和626名对照，爱尔兰高密度精神分裂症家族研究（ISHDSF）中的1350个样本包含273个家系，以及564名无血缘关系的精神分裂症患者和564名中国病例对照样本中的健康个体。使用斯坦利医学研究所（SMRI）提供的死后脑cdna，比较了精神分裂症患者和未受影响的对照组中SYN3的表达水平。在爱尔兰或中国的病例对照样本中，以及合并样本中，均无显著关联。与这一发现一致，当我们使用谱系不平衡测试来分析爱尔兰家庭样本时，我们没有发现等位基因或单倍型频率有任何显著差异。在表达研究中，患者与对照组无显著差异（p=0.507）。关联研究和表达研究都不支持SYN3在爱尔兰和中国人群中精神分裂症易感性中的主要作用。
The synapsin III gene, SYN3, which belongs to the family of synaptic vesicle-associated proteins, has been implicated in the modulation of neurotransmitter release and in synaptogenesis, suggesting a potential role in several neuropsychiatric diseases. The human SYN3 gene is located on chromosome 22q12–13, a candidate region implicated in previous linkage studies of schizophrenia. However, association studies of SYN3 and schizophrenia have produced inconsistent results. In this study, four SYN3 SNPs (rs133945(−631c>g), rs133946(−196g>a), rs9862 and rs1056484) were tested in three sets of totally 3759 samples that comprise 655 affected subjects and 626 controls in the Irish Case-Control Study of Schizophrenia (ICCSS), 1350 samples incorporating 273 pedigrees in the Irish Study of High Density Schizophrenia Families (ISHDSF), and 564 unrelated schizophrenia patients and 564 healthy individuals in a Chinese case-control sample. The expression levels of SYN3 in schizophrenic patients and unaffected controls were compared using postmortem brain cDNAs provided by the Stanley Medical Research Institute (SMRI). There was no significant association in either the Irish or Chinese case-control samples, nor in the combined samples. Consistent with this finding, we did not find any significant difference in allele or haplotype frequencies when we used the pedigree disequilibrium test to analyze the Irish family sample. In the expression studies, no significant difference (p=0.507) was observed between patients and controls. Both the association studies and expression studies didn’t support a major role for SYN3 in the susceptibility of schizophrenia in Irish and Chinese populations.
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影响因子：
3.2
作者：
Imai, K;Harada, S;Suzuki, T
通讯作者：
Suzuki, T
影响因子：
5.3
作者：
Feng, J;Chi, P;Greengard, P
通讯作者：
Greengard, P
影响因子：
2.1
作者：
Dudbridge, F
通讯作者：
Dudbridge, F
DOI：
10.1073/pnas.95.8.4667
发表时间：
1998-04-14
影响因子：
11.1
作者：
Kao, HT;Porton, B;Greengard, P
通讯作者：
Greengard, P
DOI：
10.1016/s1050-3862(98)00019-9
发表时间：
1999-02-01
期刊：
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING
影响因子：
--
作者：
Livak, KJ
通讯作者：
Livak, KJ