CIGARETTE-SMOKING, ALCOHOL, TEA AND COFFEE CONSUMPTION AND PANCREAS CANCER RISK - A CASE-CONTROL STUDY FROM OPOLE, POLAND
CIGARETTE-SMOKING, ALCOHOL, TEA AND COFFEE CONSUMPTION AND PANCREAS CANCER RISK - A CASE-CONTROL STUDY FROM OPOLE, POLAND
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DOI：
10.1002/ijc.2910530413
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发表时间：
1993-02-20
影响因子：
6.4
通讯作者：
WALKER, AM
中科院分区：
文献类型：
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作者：
ZATONSKI, WA;BOYLE, P;WALKER, AM
在国际癌症研究机构 SEARCH 计划的框架内，在波兰奥波莱开展了一项基于人群的胰腺癌病例对照研究：这是波兰报告的第一项胰腺癌病因学研究，自 1963 年以来，该国报告的死亡率增加了一倍。这项胰腺癌研究提供了一些进一步的支持证据，证明胰腺风险增加与吸烟水平增加之间存在关联。随着终生香烟消费量的增加，风险也随之增加，且趋势较弱（p = 0.061）。关于终生喝茶和咖啡的研究结果与摄入任何一种饮料都会增加患这种疾病的风险并不一致。随着终生茶消费量的增加，风险呈显着下降趋势（p < 0.001），当分析仅限于直接访谈的受试者时，这一点也很明显。对于波兰咖啡消费量较低的咖啡消费量而言，数据中也存在明显的负相关关系，而在直接访谈的受试者子集中，这种负相关关系并不具有统计显着性。尽管考虑到波兰烈酒（伏特加）来源的特殊性，烈酒消费风险的弱正趋势（p = 0.71）可能值得进一步调查，但有关酒精饮料的研究结果总体上是无效的。
A population-based, case-control study of pancreas cancer was undertaken in Opole, Poland, within the framework of the SEARCH Programme of the International Agency for Research on Cancer: this is the first aetiological study of pancreas cancer reported from Poland where the reported mortality rate has doubled since 1963. This study of pancreas cancer has provided some further supporting evidence of an association between increased pancreas risk with increasing levels of cigarette smoking. The risk rose with increasing lifetime cigarette consumption with a trend which was weakly significant (p = 0.061). Findings regarding lifetime tea and coffee consumption were not consistent with intake of either beverage increasing the risk of this disease. There was a strongly significant trend of decreasing risk with increasing lifetime consumption of tea (p < 0.001), which was also apparent when the analysis was restricted to subjects who were interviewed directly. For coffee consumption, which is low in Poland, there was also a negative association apparent in the data which was not statistically significant among the sub-set of subjects who were directly interviewed. The findings regarding alcoholic beverages were overall null, although the weakly positive trend in risk with spirits consumption (p = 0.71) may deserve further investigation in view of the special nature of the source of spirits (vodka) in Poland.