What is the best proton energy for accelerator-based BNCT using the 7Li(p,n)7Be reaction?
What is the best proton energy for accelerator-based BNCT using the 7Li(p,n)7Be reaction?
复制标题
使用 7Li(p,n)7Be 反应的基于加速器的 BNCT 的最佳质子能量是多少？
DOI：
10.1118/1.598976
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发表时间：
2000
期刊：
影响因子：
3.8
通讯作者：
T. Beynon
中科院分区：
文献类型：
--
作者：
D. Allen;T. Beynon
随着人们对使用基于加速器的超热中子源用于BNCT计划的兴趣越来越大，特别是那些基于7Li（p，n）7Be反应的超热中子源，需要解决“使用什么是最好的质子能量？“本文通过使用辐射输运计算来研究质子能量从2.15到3.5 MeV的范围和一系列减速剂尺寸来考虑这个问题。本研究完全不再使用空治疗射束参数，而是使用广泛接受的体模内治疗计划优值来定义射束质量并优化减速器设计。得出的结论是，高达约2.8 MeV的质子能量，可实现的治疗束质量没有观察到变化，但因未选择该范围的上限而在治疗时间方面付出了代价。对于更高的质子能量，射束质量福尔斯下降，但对于最佳配置，治疗时间没有改善。
With a growing interest in the use of accelerator-based epithermal neutron sources for BNCT programs, in particular those based upon the 7Li(p,n)7Be reaction, there is a need to address the question of "what is the best proton energy to use?" This paper considers this question by using radiation transport calculations to investigate a range of proton energies from 2.15 to 3.5 MeV and a range of moderator sizes. This study has moved away completely from the use of empty therapy beam parameters and instead defines the beam quality and optimizes the moderator design using widely accepted in-phantom treatment planning figures of merit. It is concluded that up to a proton energy of about 2.8 MeV there is no observed variation in the achievable therapy beam quality, but a price is paid in terms of treatment time for not choosing the upper limit of this range. For higher proton energies, the beam quality falls, but with no improvement in treatment time for optimum configurations.