Combining Concentrated Autologous Bone Marrow Stem Cells Injection With Core Decompression Improves Outcome for Patients with Early-Stage Osteonecrosis of the Femoral Head: A Comparative Study
Combining Concentrated Autologous Bone Marrow Stem Cells Injection With Core Decompression Improves Outcome for Patients with Early-Stage Osteonecrosis of the Femoral Head: A Comparative Study
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DOI：
10.1016/j.arth.2015.06.022
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发表时间：
2015-09-01
影响因子：
3.5
通讯作者：
Farzan, Mahmoud
中科院分区：
文献类型：
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作者：
Tabatabaee, Reza Mostafavi;Saberi, Sadegh;Farzan, Mahmoud
早期股骨头坏死(ONFH)的治疗仍然具有挑战性。本研究旨在评价髓核减压术和浓缩骨髓植入治疗股骨头坏死的疗效。这项研究招募了28个早期ONFH患者，随机分为两组：髓芯减压组(A组)和不注射骨髓组(B组)。使用西安大略大学和麦克马斯特大学骨关节炎指数(WOMAC)问卷、视觉模拟评分(VAS)疼痛指数和MRI对患者进行评估。所有患者的WOMAC和VAS值均有显著改善(P<；0.001)。核磁共振显示A组明显改善(P=0.046)，B组显著恶化(P<；0.001)。骨髓干细胞注射加髓核减压术可有效治疗早期ONFH。(C)2015 Elsevier Inc.保留所有权利。
Themanagement of early-stage osteonecrosis of the femoral head (ONFH) remains challenging. This study aimed to evaluate the effects of core decompression and concentrated bone marrow implantation on ONFH. The study recruited 28 hips with early ONFH randomly assigned into two groups of core decompression with (group A) and without (group B) bone marrow injection. Patients were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, Visual Analogue Scale (VAS) pain index, and MRI. The mean WOMAC and VAS scores in all patients improved significantly (P < 0.001). MRI showed a significant improvement in group A (P = 0.046) and significant worsening in group B (P < 0.001). Bone marrow stem cell injection with core decompression can be effective in early ONFH. (C) 2015 Elsevier Inc. All rights reserved.