Disruption of the Fanconi anemia/BRCA pathway in sporadic cancer
Disruption of the Fanconi anemia/BRCA pathway in sporadic cancer
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DOI：
10.1016/j.canlet.2005.07.038
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发表时间：
2006-01-28
期刊：
影响因子：
9.7
通讯作者：
Surralles, J
中科院分区：
文献类型：
--
作者：
Lyakhovich, A;Surralles, J
越来越多的研究提供了证据，证明Fanconi贫血/BRCA级联的中断与散发性癌症有关。鉴于这一途径对DNA链间交叉连接的反应起着至关重要的作用，这些癌症有望对基于交叉连接的治疗具有化疗敏感性。在这篇简短的综述中，我们扩展了FA/BRCA中断的可能性范围，并回顾了一些描述FA/BRCA通路中断与散发性癌症相关的上游和下游功能事件的工作。这可能涉及但不限于FA-核心复合体或BRCA1/2的表观遗传沉默，一个或几个FA-BRCA基因的AM突变或编码产物的修饰。这可能为散发性癌症的发生、发展和治疗提供一个平台，因此值得成为新的研究方向的重点。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
An increasing number of studies provide evidences linking disruption of Fanconi anemia/BRCA cascade with sporadic cancers. Given that this pathway plays essential roles in response to the DNA interstrand cross-links, these cancers are expected to be chemosensitive to cross-link based therapy. In the present mini-review we expand the spectrum of possibilities for FA/BRCA disruption and review some works describing functional upstream and downstream events linking disruption of the FA/BRCA pathway to sporadic cancer. This may involve but not limited to epigenetic silencing of the FA-core complex or BRCA1/2, AM mutations of one or several FA-BRCA genes or modification of encoded products. All this may serve as a platform for occurrence, development and treatment of sporadic cancers and therefore deserves to be in the focus of new research directions. (c) 2005 Elsevier Ireland Ltd. All rights reserved.