Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers
Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers
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DOI：
10.1016/j.neuroimage.2008.03.036
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发表时间：
2008-07-15
期刊：
影响因子：
5.7
通讯作者：
de Crespignya, A. J.
中科院分区：
文献类型：
--
作者：
Wedeen, V. J.;Wang, R. P.;de Crespignya, A. J.
MRI纤维束成像是基于组织扩散各向异性的扩散MRI来绘制神经纤维通路。基于扩散张量成像 (DTI) 的纤维束成像无法直接对单个体素内的多个纤维方向进行成像。为了解决这一限制，开发了扩散谱 MRI (DSI) 和相关方法来对体素内纤维方向的复杂分布进行成像。在这里，我们证明基于 DSI 的纤维束成像能够对神经组织中的交叉纤维进行成像。 DSI 在福尔马林固定的成年猕猴大脑和健康人类受试者的大脑中进行。纤维束解决方案通过简化程序构建，遵循每个点的最大扩散方向，并在交互式可视化环境 (TrackVis) 中进行分析。我们报告说，DSI 纤维束成像准确地显示了视交叉、半卵圆中心和脑干中已知的解剖纤维交叉；灰质中的纤维交叉点，包括小脑叶和尾状核；和大脑皮层的放射状纤维结构。相比之下，这些纤维交叉和复杂结构的例子都没有通过对相同数据集的 DTI 分析来识别。这些发现表明 DSI 纤维束成像能够对神经组织中的交叉纤维进行成像，这是连接神经解剖学非侵入性成像的重要一步。 (c) 2008 年，爱思唯尔公司出版。
MRI tractography is the mapping of neural fiber pathways based on diffusion MRI of tissue diffusion anisotropy. Tractography based on diffusion tensor imaging (DTI) cannot directly image multiple fiber orientations within a single voxel. To address this limitation, diffusion spectrum MRI (DSI) and related methods were developed to image complex distributions of intravoxel fiber orientation. Here we demonstrate that tractography based on DSI has the capacity to image crossing fibers in neural tissue. DSI was performed in formalin- fixed brains of adult macaque and in the brains of healthy human subjects. Fiber tract solutions were constructed by a streamline procedure, following directions of maximum diffusion at every point, and analyzed in an interactive visualization environment (TrackVis). We report that DSI tractography accurately shows the known anatomic fiber crossings in optic chiasm, centrum semiovale, and brainstem; fiber intersections in gray matter, including cerebellar folia and the caudate nucleus; and radial fiber architecture in cerebral cortex. In contrast, none of these examples of fiber crossing and complex structure was identified by DTI analysis of the same data sets. These findings indicate that DSI tractography is able to image crossing fibers in neural tissue, an essential step toward non-invasive imaging of connectional neuroanatomy. (c) 2008 Published by Elsevier Inc.