SERPINB7 Expression Predicts Poor Pancreatic Cancer Survival Upon Gemcitabine Treatment.
SERPINB7 Expression Predicts Poor Pancreatic Cancer Survival Upon Gemcitabine Treatment.
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DOI：
10.1016/j.tranon.2018.08.019
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发表时间：
2019-01
影响因子：
5
通讯作者：
Prager GW
中科院分区：
文献类型：
--
作者：
Bianconi D;Herac M;Spies D;Kieler M;Brettner R;Unseld M;Fürnkranz K;Famler B;Schmeidl M;Minichsdorfer C;Zielinski C;Heller G;Prager GW
胰腺导管腺癌（PDAC）患者的分层仍然是临床肿瘤学领域的一个关键挑战。尚未发现任何可用治疗方案的预测生物标志物。先前，我们鉴定了SERPINB 7作为PDAC的推定生物标志物，因此，在本文中，我们旨在验证我们先前的发现并评估SERPINB 7的预测价值。本研究纳入了2011年至2017年期间接受手术并接受吉西他滨（gem）或吉西他滨+nab-紫杉醇（gem/nab）作为辅助治疗的患者（n = 57）。采用免疫组化（IHC）和RNA原位杂交（RNA ISH）检测肿瘤组织中SERPINB 7的表达水平。研究其与无病生存期（DFS）和总生存期（OS）的关系。虽然IHC未显示存活率与SERPINB 7蛋白水平之间的任何相关性，但RNA ISH显示，在gem组中，SERPINB 7的表达与较差的DFS（P = .01）和OS（P = .002）相关，但在gem/nab中则不相关。校正的Cox回归分析证实了gem组中SERPINB 7对OS的独立预测值（P = 0.006，HR：3.47; 95% CI：1.49-8.09）。总之，SERPINB 7被鉴定为PDAC的第一个预测性RNA生物标志物。这项研究表明，表达SERPINB 7的患者可能会接受另一种治疗，而不是单独使用GEM。
Stratification of patients with pancreatic ductal adenocarcinoma (PDAC) remains a key challenge in the field of clinical oncology. No predictive biomarkers have yet been found for any available treatment options. Previously, we identified SERPINB7 as a putative biomarker for PDAC and thus, herein, we aimed to validate our previous findings and assessed the predictive value of SERPINB7. Patients who underwent surgery and received gemcitabine (gem) or gemcitabine plus nab-paclitaxel (gem/nab) as adjuvant therapy, between 2011 and 2017, were included in this study (n = 57). Expression level of SERPINB7 was assessed in tumor tissue by immunohistochemistry (IHC) and RNA in situ hybridization (RNA ISH). Its association with disease-free survival (DFS) and overall survival (OS) was investigated. While IHC did not show any correlation between survival and the protein level of SERPINB7, RNA ISH revealed that expression of SERPINB7 was associated with a poor DFS (P = .01) and OS (P = .002) in the gem group but not in the gem/nab. Adjusted Cox-regression analysis confirmed the independent predictive value of SERPINB7 on OS (P = .006, HR: 3.47; 95% CI: 1.49–8.09) in the gem group. In conclusion, SERPINB7 was identified as the first predictive RNA biomarker for PDAC. This study suggests that patients who expressed SERPINB7 might receive another treatment than gem alone.
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影响因子：
64.8
作者：
Notta F;Chan-Seng-Yue M;Lemire M;Li Y;Wilson GW;Connor AA;Denroche RE;Liang SB;Brown AM;Kim JC;Wang T;Simpson JT;Beck T;Borgida A;Buchner N;Chadwick D;Hafezi-Bakhtiari S;Dick JE;Heisler L;Hollingsworth MA;Ibrahimov E;Jang GH;Johns J;Jorgensen LG;Law C;Ludkovski O;Lungu I;Ng K;Pasternack D;Petersen GM;Shlush LI;Timms L;Tsao MS;Wilson JM;Yung CK;Zogopoulos G;Bartlett JM;Alexandrov LB;Real FX;Cleary SP;Roehrl MH;McPherson JD;Stein LD;Hudson TJ;Campbell PJ;Gallinger S
通讯作者：
Gallinger S
影响因子：
12.3
作者：
Law RH;Zhang Q;McGowan S;Buckle AM;Silverman GA;Wong W;Rosado CJ;Langendorf CG;Pike RN;Bird PI;Whisstock JC
通讯作者：
Whisstock JC
DOI：
10.1158/1078-0432.ccr-14-2600
发表时间：
2015-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dal Molin M;Zhang M;de Wilde RF;Ottenhof NA;Rezaee N;Wolfgang CL;Blackford A;Vogelstein B;Kinzler KW;Papadopoulos N;Hruban RH;Maitra A;Wood LD
通讯作者：
Wood LD
影响因子：
15.9
作者：
Miyata, T;Inagi, R;Kurokawa, K
通讯作者：
Kurokawa, K
影响因子：
64.8
作者：
Biankin, Andrew V.;Waddell, Nicola;Kassahn, Karin S.;Gingras, Marie-Claude;Muthuswamy, Lakshmi B.;Johns, Amber L.;Miller, David K.;Wilson, Peter J.;Patch, Ann-Marie;Wu, Jianmin;Chang, David K.;Cowley, Mark J.;Gardiner, Brooke B.;Song, Sarah;Harliwong, Ivon;Idrisoglu, Senel;Nourse, Craig;Nourbakhsh, Ehsan;Manning, Suzanne;Wani, Shivangi;Gongora, Milena;Pajic, Marina;Scarlett, Christopher J.;Gill, Anthony J.;Pinho, Andreia V.;Rooman, Ilse;Anderson, Matthew;Holmes, Oliver;Leonard, Conrad;Taylor, Darrin;Wood, Scott;Xu, Qinying;Nones, Katia;Fink, J. Lynn;Christ, Angelika;Bruxner, Tim;Cloonan, Nicole;Kolle, Gabriel;Newell, Felicity;Pinese, Mark;Mead, R. Scott;Humphris, Jeremy L.;Kaplan, Warren;Jones, Marc D.;Colvin, Emily K.;Nagrial, Adnan M.;Humphrey, Emily S.;Chou, Angela;Chin, Venessa T.;Chantrill, Lorraine A.;Mawson, Amanda;Samra, Jaswinder S.;Kench, James G.;Lovell, Jessica A.;Daly, Roger J.;Merrett, Neil D.;Toon, Christopher;Epari, Krishna;Nguyen, Nam Q.;Barbour, Andrew;Zeps, Nikolajs;Kakkar, Nipun;Zhao, Fengmei;Wu, Yuan Qing;Wang, Min;Muzny, Donna M.;Fisher, William E.;Brunicardi, F. Charles;Hodges, Sally E.;Reid, Jeffrey G.;Drummond, Jennifer;Chang, Kyle;Han, Yi;Lewis, Lora R.;Dinh, Huyen;Buhay, Christian J.;Beck, Timothy;Timms, Lee;Sam, Michelle;Begley, Kimberly;Brown, Andrew;Pai, Deepa;Panchal, Ami;Buchner, Nicholas;De Borja, Richard;Denroche, Robert E.;Yung, Christina K.;Serra, Stefano;Onetto, Nicole;Mukhopadhyay, Debabrata;Tsao, Ming-Sound;Shaw, Patricia A.;Petersen, Gloria M.;Gallinger, Steven;Hruban, Ralph H.;Maitra, Anirban;Iacobuzio-Donahue, Christine A.;Schulick, Richard D.;Wolfgang, Christopher L.;Morgan, Richard A.;Lawlor, Rita T.;Capelli, Paola;Corbo, Vincenzo;Scardoni, Maria;Tortora, Giampaolo;Tempero, Margaret A.;Mann, Karen M.;Jenkins, Nancy A.;Perez-Mancera, Pedro A.;Adams, David J.;Largaespada, David A.;Wessels, Lodewyk F. A.;Rust, Alistair G.;Stein, Lincoln D.;Tuveson, David A.;Copeland, Neal G.;Musgrove, Elizabeth A.;Scarpa, Aldo;Eshleman, James R.;Hudson, Thomas J.;Sutherland, Robert L.;Wheeler, David A.;Pearson, John V.;McPherson, John D.;Gibbs, Richard A.;Grimmond, Sean M.
通讯作者：
Grimmond, Sean M.