Fast X-Ray Luminescence Computed Tomography Imaging
Fast X-Ray Luminescence Computed Tomography Imaging
复制标题
快速 X 射线发光计算机断层扫描成像
DOI：
10.1109/tbme.2013.2294633
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发表时间：
2014-06-01
影响因子：
4.6
通讯作者：
Wang, Hongkai
中科院分区：
文献类型：
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作者：
Liu, Xin;Liao, Qimei;Wang, Hongkai
X射线荧光计算机断层扫描（XLCT）开辟了新的可能性，执行分子成像与X射线。然而，动态XLCT成像仍然面临挑战，应同时考虑短扫描时间、良好的空间分辨率和全身视野。在本文中，通过使用基于压缩传感（CS）技术的单视图XLCT重建方法，结合锥形束XLCT成像系统，我们实现了快速三维XLCT成像。为了评估该方法的性能，两种类型的体模实验进行了基于锥束XLCT成像系统。在病例1中，将一个填充有X射线可激发纳米荧光粉（Gd 2 O3：Eu 3+）的管浸入体模中的不同位置，以评估源位置对单视图XLCT重建精度的影响。在病例2中，将两个填充Gd 2 O3：Eu 3+的管以不同高度浸入体模中，以评价单视图XLCT重建的全身成像性能。实验结果表明，在以前的体模实验中使用的管可以解决从单视图XCLT重建图像。定位误差小于1.2 mm。此外，由于只需要一个视图数据来实现3-D XLCT成像，与以前的XLCT系统相比，采集时间可以大大减少（约1帧/秒）。因此，该技术适用于对生物对象内的X射线可激发纳米荧光粉的快速分布进行成像。
X-ray luminescence computed tomography (XLCT) opens new possibilities to perform molecular imaging with X-ray. However, challenges remain in dynamic XLCT imaging, where short scan time, good spatial resolution, and whole-body field of view should be considered simultaneously. In this paper, by the use of a single-view XLCT reconstruction method based on a compressive sensing (CS) technique, incorporating a cone beam XLCT imaging system, we implement fast 3-D XLCT imaging. To evaluate the performance of the method, two types of phantom experiments were performed based on a cone beam XLCT imaging system. In Case 1, one tube filled with the X-ray-excitable nanophosphor (Gd2O3:Eu3+) was immerged in different positions in the phantom to evaluate the effect of the source position on single-view XLCT reconstruction accuracy. In Case 2, two tubes filled with Gd2O3:Eu3+ were immerged in different heights in the phantom to evaluate the whole-body imaging performance of single-view XLCT reconstruction. The experimental results indicated that the tubes used in previous phantom experiments can be resolved from single-view XCLT reconstruction images. The location error is less than 1.2 mm. In addition, since only one view data are needed to implement 3-D XLCT imaging, the acquisition time can be greatly reduced (~1 frame/s) compared with previous XLCT systems. Hence, the technique is suited for imaging the fast distribution of the X-ray-excitable nanophosphors within a biological object.