Cinnamic acid as one of the antidiabetic active principle(s) from the seeds of Syzygium alternifolium
Cinnamic acid as one of the antidiabetic active principle(s) from the seeds of Syzygium alternifolium
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DOI：
10.1016/j.fct.2012.02.003
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发表时间：
2012-05-01
影响因子：
4.3
通讯作者：
Apparao, Chippada
中科院分区：
文献类型：
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作者：
Kasetti, Ramesh Babu;Nabi, Shaik Abdul;Apparao, Chippada
印度的传统医学体系规定植物疗法治疗包括糖尿病在内的疾病。一种这样的植物是互叶蒲桃（Syzygium alternifolium，SA）。我们以前报道过，SA种子水提物的组分C显示出良好的降血糖和降血脂活性。在延续它，我们已经进行了生物测定指导分馏馏分C和确定肉桂酸作为一个组成部分具有抗高血糖活性。通过对STZ诱导的糖尿病大鼠口服C组分（50 mg/kg B.w），每日一次，连续30天，进行了详细的研究，以阐明其抗糖尿病作用的模式。给药组份C可使糖尿病大鼠肝、肾糖代谢酶活性明显恢复至正常水平（P < 0.01）。组分C在治疗后立即降低了血糖，并在30天治疗后对与葡萄糖稳态相关的酶活性产生了格列本脲样调节作用，表明肉桂酸可用于糖尿病管理。(C)2012爱思唯尔有限公司保留所有权利。
The Indian traditional system of medicine prescribed plant therapies for diseases including diabetes mellitus. One such plant is Syzygium alternifolium (SA). We reported earlier, that fraction C from aqueous extract of SA seeds showed good antihyperglycemic and antihyperlipidemic activities. In continuation to it, we have performed bioassay guided fractionation of fraction C and identified cinnamic acid as a component with antihyperglycemic activity. A detailed study was undertaken to elucidate its mode of antidiabetic action by giving fraction C (50 mg/kg b.w) orally, once a day for 30 days in STZ induced diabetic rats. The altered enzyme activities of carbohydrate metabolism in liver and kidney of diabetic rats were significantly (p < 0.01) reverted to near normal levels by the administration of fraction C. Fraction C lowered blood glucose as expected, immediately following treatment, and led to glibenclamide-like modulatory effects on enzyme activities related to glucose homeostasis after 30 days treatment, indicating that cinnamic acid may prove useful in diabetes management. (C) 2012 Elsevier Ltd. All rights reserved.