A case of sarcoidosis with eosinophilia in peripheral blood and bronchoalveolar lavage fluid.
A case of sarcoidosis with eosinophilia in peripheral blood and bronchoalveolar lavage fluid.
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DOI：
10.1016/j.rmcr.2013.01.004
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发表时间：
2013
影响因子：
1.1
通讯作者：
Nishimura, Masaharu
中科院分区：
文献类型：
--
作者：
Takahashi, Ayumu;Konno, Satoshi;Hatanaka, Kanako;Matsuno, Yoshihiro;Yamaguchi, Etsuro;Nishimura, Masaharu
70岁女性，38岁确诊结节病，双侧肺野新出现弥漫性磨玻璃样混浊，双侧肺门及纵隔淋巴结肿大。根据支气管肺泡灌洗液（BALF）的检查结果和病理分析，怀疑嗜酸性粒细胞性肺炎伴结节病。两种疾病（结节病和BALF嗜酸性粒细胞增多）同时恶化和改善，在随访期间她出现了两次类似的发作。本病例促使我们对2000年至2009年在我科诊断为结节病的178例患者（不包括本患者）的外周血嗜酸性粒细胞百分比和BALF进行回顾性调查。178例患者中，BALF中嗜酸性粒细胞百分比最高，为2.6%；相反，外周血嗜酸性粒细胞增多非常常见。因此，我们得出结论，对于结节病患者，在BALF中观察到的明显嗜酸性粒细胞增多是例外，正如这位70岁女性的病例所示。
A 70-year-old woman, who has had a diagnosis of sarcoidosis since she was 38 years old, showed newly appearing diffuse ground-glass opacities in the bilateral lung field, and bilateral enlargement of the hilar and mediastinal lymph nodes. Based on findings from bronchoalveolar lavage fluid (BALF) and pathology analysis, eosinophilic pneumonia accompanied by sarcoidosis was suspected. Both disease conditions (sarcoidosis and BALF eosinophilia) worsened and improved simultaneously, and she showed two similar episodes during the follow-up. This case prompted us to conduct a retrospective investigation of eosinophil percentage in peripheral blood and BALF in 178 patients (excluding our patient) who had received a diagnosis of sarcoidosis between 2000 and 2009 in our department. Among the 178 patients, the highest eosinophil percentage in BALF was 2.6%; in contrast, peripheral blood eosinophilia was very common. Thus we concluded that, for subjects with sarcoidosis, marked eosinophilia in BALF, as observed in the case of this 70-year-old woman, was exceptional.