Essential role of mouse telomerase in highly proliferative organs
Essential role of mouse telomerase in highly proliferative organs
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DOI：
10.1038/33345
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发表时间：
1998-04-09
期刊：
影响因子：
64.8
通讯作者：
DePinho, RA
中科院分区：
文献类型：
--
作者：
Lee, HW;Blasco, MA;DePinho, RA
我们研究了端粒酶在连续几代缺乏端粒酶RNA的小鼠高度增殖器官中的作用。后代动物表现出精子发生缺陷，睾丸中程序性细胞死亡（凋亡）增加，增殖减少。骨髓和脾脏中造血细胞的增殖能力也受到损害。这些进行性不良反应与端粒（真核染色体的末端）的大量侵蚀以及染色体的融合和丢失相一致。这些研究结果表明，端粒酶，因此端粒，在维持基因组的完整性和高更新器官系统的长期生存能力的重要作用。
We have investigated the role of the enzyme telomerase in highly proliferative organs in successive generations of mice lacking telomerase RNA. Late-generation animals exhibited defective spermatogenesis, with increased programmed cell death (apoptosis) and decreased proliferation in the testis. The proliferative capacity of haematopoietic cells In the bone marrow and spleen was also compromised. These progressively adverse effects coincided with substantial erosion of telomeres (the termini of eukaryotic chromosomes) and fusion and loss of chromosomes. These findings indicate an essential role for telomerase, and hence telomeres, in the maintenance of genomic integrity and in the long-term viability of high-renewal organ systems.