Glutamate and other CSF amino acids in Alzheimer's disease.
Glutamate and other CSF amino acids in Alzheimer's disease.
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阿尔茨海默病中的谷氨酸和其他脑脊液氨基酸。
DOI：
10.1176/ajp.149.2.251
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
P. LeWitt
中科院分区：
文献类型：
--
作者：
N. Pomara;Rajkumar Singh;D. Deptula;J. Chou;Miriam Banay Schwartz;P. LeWitt
作者比较了10名从未接受过抗抑郁或抗精神病药物治疗的轻度至中度痴呆和可能患有阿尔茨海默病的患者与10名年龄相仿的正常受试者的脑脊液氨基酸水平。阿尔茨海默病患者的脑脊液谷氨酸水平明显较高。这一发现与年龄、性别或痴呆症的严重程度无关。脑脊液谷氨酸升高可能反映了阿尔茨海默病早期更大的谷氨酸能活性。作者推测，谷氨酸的兴奋毒性作用可能有助于阿尔茨海默病的进行性神经元丧失。
The authors compared CSF amino acid levels of 10 patients with mild to moderate dementia and probable Alzheimer's disease who had never received antidepressant or neuroleptic medication with those of 10 normal subjects of similar age. The Alzheimer's patients had significantly higher levels of CSF glutamate. This finding was not related to age, sex, or severity of dementia. Elevated CSF glutamate may reflect greater glutamatergic activity early in the course of Alzheimer's disease. The authors speculate that the excitotoxic effects of glutamate may contribute to progressive neuronal loss in Alzheimer's disease.