Surfactant protein A modulates induction of regulatory T cells via TGF-β.
Surfactant protein A modulates induction of regulatory T cells via TGF-β.
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DOI：
10.4049/jimmunol.1101775
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发表时间：
2012-05-01
期刊：
影响因子：
--
通讯作者：
Wright JR
中科院分区：
文献类型：
--
作者：
Mukherjee S;Giamberardino C;Thomas JM;Gowdy K;Pastva AM;Wright JR
T cell receptor (TCR) signaling plays a critical role in regulatory T cell (Treg) development. However, the mechanism for tissue specific induction of Tregs in the periphery remains unclear. We observed that surfactant protein A (SP-A) deficient mice have impaired expression of Foxp3 and fewer CD25+Foxp3+ Treg cells after ex vivo stimulation and after stimulation with lipopolysaccharide (LPS) in vivo. The addition of exogenous SP-A completely reversed this phenotype. Although SP-A is known to inhibit T cell proliferation under certain activation conditions, both IL-2 levels as well as active TGFβ levels increase on extended culture with exogenous SP-A, providing a key mechanism for the maintenance and induction of Tregs. In addition, kinetic suppression assays demonstrate that SP-A enhances the frequency of functional Foxp3+Tregs in responder T cell populations in a TGFβ-dependent manner. In mice treated with LPS in vivo, Tregs increased ~160% in WT mice compared to only a 50% increase in LPS treated SP-A−/− mice eight days after exposure. Together, these findings support the hypothesis that SP-A affects T cell immune function by the induction of regulatory T cells during activation.
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影响因子：
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