Persisting Haemophilus influenzae strains induce lower levels of interleukin-6 and interleukin-8 in H292 lung epithelial cells than nonpersisting strains
Persisting Haemophilus influenzae strains induce lower levels of interleukin-6 and interleukin-8 in H292 lung epithelial cells than nonpersisting strains
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DOI：
10.1183/09031936.97.10102319
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发表时间：
1997-10-01
影响因子：
24.3
通讯作者：
Lutter, R
中科院分区：
文献类型：
--
作者：
Bresser, P;vanAlphen, L;Lutter, R
从慢性支气管炎患者中分离出的非包膜流感嗜血杆菌菌株可分为在下呼吸道中持续存在的菌株和未在下呼吸道中持续存在的菌株。我们测试了以下假设：持久性菌株和非持久性菌株激活上皮细胞产生两种强效炎症介质白细胞介素 (IL)-6 和 IL-8 的程度不同。10(7) 和 10(8) 集落形成单位的悬浮液(cfu).mL(-1) 持久性和非持久性流感嗜血杆菌，诱导人肺粘液表皮样癌衍生细胞系 H292 产生剂量和时间依赖性的 IL-6 和 IL-8，但暴露于持久性流感嗜血杆菌后，IL-6 水平较低 (p
Nonencapsulated Haemophilus influenzae strains isolated from patients with chronic bronchitis can be divided into those that persist in the lower respiratory tract and those that do not, We tested the hypothesis that persisting and nonpersisting strains differ in the extent to which they activate epithelial cells to produce two potent inflammatory mediators, interleukin (IL)-6 and IL-8.A suspension of 10(7) and 10(8) colony forming units (cfu).mL(-1) of H. influenzae, persisting and nonpersisting, induced a dose-and time-dependent production of IL-6 and IL-8 by the human pulmonary mucoepidermoid carcinoma-derived cell line H292, but levels of IL-6 were lower after exposure to persisting H. influenzae (p