Nitrous oxide-isoflurane anesthesia causes more cerebral vasodilation than an equipotent dose of isoflurane in humans.
Nitrous oxide-isoflurane anesthesia causes more cerebral vasodilation than an equipotent dose of isoflurane in humans.
复制标题
一氧化二氮-异氟烷麻醉比等量剂量的异氟烷对人体造成更多的脑血管舒张。
作者：
Arthur M. Lam;T. S. Mayberg;C. Eng;Kenneth L. Bachenberg;Terri;L.;Mathisen
比较异氟醚-一氧化二氮混合物与等效剂量的异氟醚在1.1最小肺泡麻醉剂浓度（MAC）下对脑血管和代谢的影响，并研究一氧化二氮和异氟醚麻醉之间的相互作用，测定右侧大脑中动脉血流速度（Vmca）和脑动静脉氧含量差（AVDO 2）在以下顺序的稳态麻醉条件下，在正常碳酸血症和正常体温期间的6名健康患者中：条件A，0.5 MAC异氟烷，条件B，0.5 MAC异氟烷+0.6 MAC N2 O，条件C，1.1 MAC异氟烷+0.6 MAC N2 O，和条件D，1.1 MAC异氟烷。研究入组序列随机化。1.1 MAC异氟烷（条件D）期间的V mca和AVDO 2分别为48 +/- 7 cm/s和3.9 +/- 0.6 vol%。用等效浓度的N2 O替代0.6 MAC异氟醚（条件B）导致Vmca和AVDO 2增加约20%（P < 0.05）。这些发现表明，流量的增加伴随着代谢率的更大增加。在1.1MAC异氟醚中加入0.6MAC的N_2O（条件C）也使Vmca增加（P < 0.05）。我们得出的结论是，对于人类来说，N2 O是比单独使用等效剂量的异氟烷更有效的脑血管扩张剂。
To compare the cerebral vascular and metabolic effect of an isoflurane-nitrous oxide mixture to an equipotent dose of isoflurane at 1.1 minimum alveolar anesthetic concentration (MAC), and to study the interaction between nitrous oxide and isoflurane anesthesia, we measured right middle cerebral artery blood flow velocity (V mca) and cerebral arteriovenous oxygen content difference (AVDO2) in six healthy patients during normocapnia and normothermia under the following sequence of steady-state anesthetic conditions: Condition A, 0.5 MAC of isoflurane, Condition B, 0.5 MAC of isoflurane + 0.6 MAC of N2O, Condition C, 1.1 MAC of isoflurane + 0.6 MAC of N2O, and Condition D, 1.1 MAC of isoflurane. The study entry sequence was randomized. V mca and AVDO2 during 1.1 MAC of isoflurane (Condition D) was 48 +/- 7 cm/s and 3.9 +/- 0.6 vol%, respectively. Substituting 0.6 MAC of isoflurane with an equipotent concentration of N2O (Condition B) resulted in an increase in both V mca and AVDO2 of approximately 20% (P < 0.05). These findings suggest that the increase in flow was accompanied by an even greater increase in metabolic rate. Adding 0.6 MAC of N2O to 1.1 MAC of isoflurane (Condition C) also increased V mca (P < 0.05). We conclude that N2O is a more potent cerebral vasodilator than an equipotent dose of isoflurane alone in humans.
一氧化二氮对异氟烷麻醉大鼠脑代谢率的影响。
影响因子：
9.8
作者：
Reasoner,DK;Warner,DS;Todd,MM;McAllister,A
通讯作者：
McAllister,A