Cognitive functions, fatigue, depression, anxiety, and sleep disturbances: assessment of nonmotor features in young patients with essential tremor
Cognitive functions, fatigue, depression, anxiety, and sleep disturbances: assessment of nonmotor features in young patients with essential tremor
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DOI：
10.1007/s13760-014-0396-6
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发表时间：
2015-09-01
影响因子：
2.7
通讯作者：
Ozdemir, Gokhan
中科院分区：
文献类型：
--
作者：
Sengul, Yildizhan;Sengul, Hakan S.;Ozdemir, Gokhan
越来越多的证据表明，除了运动功能外，特发性震颤（ET）患者还可能表现出显著的非运动功能，如轻度认知障碍、疲劳、神经精神症状和睡眠障碍。本研究的目的是检查年轻ET患者的非运动功能及其对生活质量的影响。采用匹兹堡睡眠质量指数、埃普沃思嗜睡量表、贝克抑郁量表、贝克焦虑量表、疲劳严重程度量表和简明36量表对45例ET患者（24.55 ± 7.16岁）和35例对照者进行评估。认知功能使用土耳其版本的蒙特利尔认知评估组合（MoCA）进行评估。我们排除了引起震颤的其他可能原因。使用Fahn-Tolosa-Marin震颤评定量表评价震颤率。患者组睡眠质量差、疲劳、焦虑和抑郁症状更常见，MoCA总分较低。疲劳、抑郁症状和较高的焦虑水平被认为对身心健康有负面影响。白天过度嗜睡对身体健康有负面影响。有一个新兴的兴趣在非运动功能的ET。这项研究表明，即使是年轻患者也有非运动功能，这会降低他们的生活质量。这可能告诉我们，非运动症状可能是疾病早期的一部分。
There is a growing amount of evidence to suggest that besides motor features, patients with essential tremor (ET) may exhibit significant nonmotor features, such as mild cognitive deficits, fatigue, neuropsychiatric symptoms, and sleep disturbances. The goal of this study was to examine nonmotor features in young patients with ET and their impact on quality of life. 45 patients (24.55 +/- 7.16 years old) with ET and 35 controls were evaluated using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, Beck Depression Inventory, Beck Anxiety Scale, Fatigue Severity Scale, and Short Form-36. Cognitive functions were evaluated using the Turkish version of the Montreal Cognitive Assessment Battery (MoCA). We ruled out other possible causes of the tremor. The tremor rate was evaluated using the Fahn-Tolosa-Marin Tremor Rating Scale. Poor sleep quality, fatigue, anxiety, and depressive symptoms were more common, and MoCA total scores were lower in the patient group. Fatigue, depressive symptoms, and higher anxiety levels were seen to have a negative effect on physical and mental health. Excessive daytime sleepiness had a negative effect on physical health. There is an emerging interest in nonmotor features of ET. This study showed that even young patients have nonmotor features that decrease their quality of life. This might tell us that nonmotor symptoms could be a part of the disease in the early stages.