The Role of PSA-NCAM in Adult Neurogenesis
The Role of PSA-NCAM in Adult Neurogenesis
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DOI：
10.1007/978-1-4419-1170-4_8
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Kiss, Jozsef Zoltan
中科院分区：
文献类型：
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作者：
Gascon, Eduardo;Vutskits, Laszlo;Kiss, Jozsef Zoltan
将新神经元吸收到现有的神经回路中是一种令人着迷的成体可塑性。在哺乳动物大脑中，这一过程发生在两个离散的区域，即侧脑室下区（SVZ）和海马齿状回亚颗粒区（SGZ）。最近的一些研究表明，携带α - 2,8-链唾液酸（polysialic acid， PSA）线性均聚物的神经细胞粘附分子（NCAM）的同型体在调节成人神经发生的几个步骤中发挥作用，包括新生成神经元的迁移、存活和过程生长。在这里，我们将回顾最近关于PSA-NCAM如何调节成人神经发生部位新神经元生物学特性的证据。
Recruitment of new neurons to existing circuits is a fascinating form of adult plasticity. In the mammalian brain, this process occurs in two discrete regions, the subventricular zone of the lateral ventricule (SVZ) and the subgranular zone of dentate gyrus (SGZ) in the hippocampus. Several recent studies suggest that isoforms of the neuronal cell adhesion molecule (NCAM) carrying the linear homopolymer of alpha 2,8-linked sialic acid (polysialic acid, PSA), play a role in regulating several steps of adult neurogenesis including migration, survival and process outgrowth of newly generated neurons. Here, we will review recent evidence on how PSA-NCAM might regulate the biological properties of new neurons in sites of adult neurogenesis.