Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
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DOI：
10.1073/pnas.94.24.13193
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发表时间：
1997-11-25
影响因子：
11.1
通讯作者：
Fauci, AS
中科院分区：
文献类型：
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作者：
Chun, TW;Stuyver, L;Fauci, AS
尽管包括蛋白酶抑制剂在内的三重药物组合形式的高效抗逆转录病毒疗法（HAART）可以将一些HIV-1感染个体的血浆病毒载量降低到无法检测的水平，但尚不清楚这些方案对潜伏感染的CD 4（+）T细胞的影响以及这些细胞在接受此类治疗的个体中HIV-1感染的持续性中发挥的作用，目前的研究表明，13例接受HAART治疗的患者中有13例的高纯度CD 4（+）T细胞，平均治疗时间为10个月，
Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to undetectable levels, it is unclear what the effects of these regimens are on latently infected CD4(+) T cells and what role these cells play in the persistence of HIV-1 infection in individuals receiving such treatment, The present study demonstrates that highly purified CD4(+) T cells from 13 of 13 patients receiving HAART with an average treatment time of 10 months and with undetectable (