Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases
Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases
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DOI：
10.1080/13550280600848399
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发表时间：
2006-06-01
影响因子：
3.2
通讯作者：
Lafon, Monique
中科院分区：
文献类型：
--
作者：
Jackson, Alan C.;Rossiter, John P.;Lafon, Monique
最近有体外证据表明，人类神经元表达先天免疫应答受体Toll样受体-3（TLR-3），并且该表达在病毒感染中增强。作者检测了TLR-3在死后人脑小脑皮质的免疫组织化学表达。发现浦肯野细胞在狂犬病（4/4）和单纯疱疹病毒性脑炎（2/2）以及肌萎缩侧索硬化（1/2）、中风（1/2）和阿尔茨海默病（3/3）的所有病例中表达TLR-3。在病毒感染的情况下，直接病毒感染是没有必要的增强神经元TLR-3的表达，这表明可溶性因子可能在诱导TLR-3的表达中发挥重要作用。除了神经元，偶尔Bergmann胶质细胞表达TLR-3在某些情况下。这项研究提供了人脑神经元可以在体内表达TLR-3的证据，并表明神经元可能在引发各种神经系统疾病的炎症反应中发挥重要作用。
There is recent in vitro evidence that human neurons express the innate immune response receptor, Toll-like receptor-3 (TLR-3), and that expression is enhanced in viral infections. The authors examined the immunohistochemical expression of TLR-3 in the cerebellar cortex of postmortem human brains. Purkinje cells were found to express TLR-3 in all cases of rabies (4 of 4) and herpes simplex encephalitis (2 of 2) as well as in cases of amyotrophic lateral sclerosis (1 of 2), stroke (1 of 2), and Alzheimer's disease (3 of 3). In cases of viral infection, direct viral infection was not necessary for enhanced neuronal TLR-3 expression, suggesting that soluble factors likely play an important role in inducing TLR-3 expression. In addition to neurons, occasional Bergmann glia expressed TLR-3 in some cases. This study has provided evidence that human brain neurons can express TLR-3 in vivo and suggests that neurons may play an important role in initiating an inflammatory reaction in a variety of neurological diseases.