Ammonium bicarbonate as porogen to make tetracycline-loaded porous bioresorbable membranes for dental guided tissue regeneration: failure due to tetracycline instability
Ammonium bicarbonate as porogen to make tetracycline-loaded porous bioresorbable membranes for dental guided tissue regeneration: failure due to tetracycline instability
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DOI：
10.1163/156856206778937262
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发表时间：
2006-01
期刊：
影响因子：
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通讯作者：
Cyril Nublat;C. Braud;H. Garreau;M. Vert
中科院分区：
文献类型：
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作者：
Cyril Nublat;C. Braud;H. Garreau;M. Vert
这项工作的目标是制造一种生物可吸收的多孔膜，旨在促进口腔手术中的骨再生和局部递送抗生素药物。所选择的设计包括多孔的聚乳酸（D, l）基质，其一侧具有封闭的光滑表面，以防止结缔组织和上皮细胞的内部迁移，而膜的其余部分呈现开放的孔隙，以允许骨性新组织的生长。选用四环素，因为其抗菌谱广，且具有成骨活性。采用溶剂铸造/颗粒浸出法和气体发泡/盐浸出法制备孔隙，由于其他研究报道氯化钠难以完全去除，因此选择碳酸氢铵作为热敏水溶性孔隙剂。成功地获得了单侧蒙皮的多孔透膜。然而，药物的有害变化被观察到分配到孔隙素的碱度，从而排除任何实际使用在体内。
The goal of this work was to manufacture a bioresorbable porous membrane aimed at both promoting osseous regeneration in oral surgery and delivering an antibiotic drug locally. The selected design consisted of a porous poly(D,L-lactic acid) matrix having a closed smooth face on one side to prevent inner migration of conjunctive and epithelial cells, and the rest of the membrane presenting open porosity to allow in-growth of osseous neotissue. The antibiotic drug was tetracycline because of its large antibacterial spectrum and its osteogenetic activity. Solvent casting/particulate leaching and gas foaming/salt leaching methods were selected to create the porosity, and ammonium bicarbonate was selected as thermosensitive water-soluble porogen because other studies reported that sodium chloride was difficult to remove totally. One-side-skinned, porous permeable membranes were successfully obtained. However, deleterious alterations of the drug were observed that were assigned to the basicity of the porogen, thus precluding any practical use in vivo.