Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women
Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women
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DOI：
10.1016/j.neurobiolaging.2008.11.002
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发表时间：
2010-12-01
影响因子：
4.2
通讯作者：
Poulin, Marc J.
中科院分区：
文献类型：
--
作者：
Brown, Allison D.;McMorris, Carly A.;Poulin, Marc J.
有氧健身对认知能力随年龄增长产生有益影响的机制尚不清楚，但可能涉及脑血管适应。在一项对社区妇女（n = 42;年龄范围= 50-90岁）的横断面研究中，我们试图确定身体健康是否与较高的脑血管功能相关，以及其与认知的关系。主要结果指标包括静息脑血流量、脑血管储备、体能（即，(V)over dotO（2）max）和认知。身体健康的女性比久坐的女性有较低的静息平均动脉压（MAP）和较高的脑血管传导性（CVC）。总体认知与年龄呈负相关，与（V）over dotO（2）max呈正相关。(V)超过dotO（2）max是静息时CVC和MAP的预测因子，当潮气末气体保持恒定在接近静息值时，CVC和MAP也是预测因子。MAP和CVC是认知功能的预测因子。这项研究确定了身体素质，血管功能和认知之间的密切联系，并提供了新的理解，健身积极影响认知与衰老的机制。这项研究的影响是相当大的，值得未来的调查。(C)2008年爱思唯尔公司All rights reserved.
The mechanisms by which aerobic fitness confers beneficial effects on cognition with aging are unclear but may involve cerebrovascular adaptations. In a cross-sectional study of women from the community (n = 42; age range = 50-90 years), we sought to determine whether physical fitness is associated with higher cerebrovascular function, and its relationship to cognition. Main outcome measures included resting cerebral blood flow, cerebrovascular reserve, physical fitness (i.e., (V) over dotO(2)max) and cognition. Physically fit women had lower resting mean arterial pressure (MAP) and higher cerebrovascular conductance (CVC) than sedentary women. Overall cognition was negatively correlated with age and positively correlated with (V) over dotO(2)max. (V) over dotO(2)max was a predictor of resting CVC and MAP, and CVC and MAP when end-tidal gases were held constant at near-resting values. MAP and CVC were predictors of cognition. This study identified strong associations between physical fitness, vascular function and cognition, and provides new understanding regarding the mechanisms by which fitness positively impacts cognition with aging. The implications of this research are considerable and warrant future investigation. (C) 2008 Elsevier Inc. All rights reserved.