4. Adjusting for Time-Varying Confounding in Survival Analysis

4. Adjusting for Time-Varying Confounding in Survival Analysis
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4. 调整生存分析中的时变混杂因素

DOI:
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发表时间:
2004
期刊:
影响因子:
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通讯作者:
N. Verbitsky
N. Verbitsky
中科院分区:
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文献类型:
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作者:
Jennifer S. Barber;S. Murphy;N. Verbitsky

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在这篇文章中,我们说明了在暴露对反应的影响的模型中直接包括内生时变混杂因素如何导致离散时间生存分析中的偏差。这种方法的另一种替代方法是Hernán,Brumback和Robins(1999)使用样本权重来调整内生时变混杂。我们讨论了这种方法何时可以用来提供无偏估计,并通过使用现有调查数据解决一个实质性的研究问题来说明该方法。我们还通过模拟分析严格地检验了加权方法对违反基本假设的稳健性。
In this paper we illustrate how directly including endogenous time-varying confounders in the model of the effect of an exposure on a response can lead to bias in discrete time survival analysis. An alternative to this method is Hernán, Brumback, and Robins' (1999) use of sample weights to adjust for endogenous time-varying confounding. We discuss when this method can be used to provide unbiased estimators, and we illustrate the method by addressing a substantive research question using existing survey data. We also critically examine the robustness of the weighting method to violations of the underlying assumptions via a simulation analysis.
DOI: 10.1097/00001648-200009000-00012
发表时间: 2000-09-01
期刊: EPIDEMIOLOGY
影响因子: 5.4
作者:
Hernán, MA;Brumback, B;Robins, JM
通讯作者: Robins, JM