Targeting B cells with biologics in systemic lupus erythematosus.
Targeting B cells with biologics in systemic lupus erythematosus.
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DOI：
10.1517/14712598.2010.524923
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发表时间：
2010-11
影响因子：
4.6
通讯作者：
La Cava A
中科院分区：
文献类型：
--
作者：
La Cava A
在一些自身免疫性疾病中使用生物制剂作为免疫调节剂，为医生的治疗手段提供了新的工具，并改善了患者的预后和生活质量。通过产生自身抗体，B细胞在SLE的发病机制和临床表现中起着关键作用。因此，SLE中靶向B细胞的生物制剂旨在降低这些细胞的活性，以诱导缓解和/或改善疾病活动性，减少器官受累，并限制免疫抑制疗法引起的并发症和副作用。这篇综述描述了过去和现在用B细胞靶向生物制剂治疗SLE的临床试验，以提供一个历史的视角和最新的研究进展。在系统性红斑狼疮（SLE）的临床试验中，基于B细胞的生物制剂的使用既有令人失望的一面，也有令人鼓舞的一面，我们将回顾有希望的药物在该领域的失望是如何有助于提供有价值的经验教训，从而改进新试验的设计，并取得令人鼓舞的结果
The use of biologics as immune modulators in several autoimmune diseases has provided new tools to the physician's therapeutic armamentiarium and has led to improved patients' outcomes and quality of life. By producing autoantibodies, B cells in SLE are key players in the pathogenesis of the disease and in its clinical manifestations. Therefore, biologics that target B cells in SLE aims at reducing the activity of these cells for the induction of remissions and/or amelioration of disease activity, reduction of organ involvement, and limitation of the complications and side effects caused by immunosuppressive therapies. This review describes the past and current clinical trials with B cell-targeted biologics in SLE, to provide a historical perspective and the state-of-the-art on the topic. We will review how the disappointment in the field from promising agents has been instrumental in providing valuable lessons leading to an improved design of new trials that are now giving encouraging results In systemic lupus erythematosus (SLE), the use of B cell-based biologics in clinical trials has shown both disappointment and promise
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影响因子：
--
作者：
Looney, RJ;Anolik, JH;Sanz, I
通讯作者：
Sanz, I
影响因子：
--
作者：
Emery, P;Fleischmann, R;Shaw, TM
通讯作者：
Shaw, TM
影响因子：
158.5
作者：
Edwards, JCW;Szczepanski, L;Shaw, T
通讯作者：
Shaw, T
影响因子：
27.4
作者：
Lavie, Frederic;Miceli-Richard, Corinne;Mariette, Xavier
通讯作者：
Mariette, Xavier
影响因子：
27.4
作者：
Jonsdottir, T.;Gunnarsson, I.;van Vollenhoven, R. F.
通讯作者：
van Vollenhoven, R. F.