Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes.
Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes.
复制标题
患有 2 型糖尿病的青少年和年轻人的动脉僵硬度存在种族差异。
DOI：
10.1111/j.1399-5448.2011.00798.x
复制
发表时间：
2012
影响因子：
3.4
通讯作者：
Urbina,ElaineM
中科院分区：
文献类型：
--
作者：
Shah,AmyS;Dolan,LawrenceM;Gao,Zhiqian;Kimball,ThomasR;Urbina,ElaineM
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes.Background: African‐American adults demonstrate a higher prevalence of cardiovascular complications including myocardial infarction and stroke. Whether similar racial disparities are present to suggest African‐Americans adolescents are at higher risk to develop cardiovascular disease is not known. Thus, we compared arterial stiffness, an early marker of cardiovascular disease, in African‐American and Caucasian adolescents and young adults with type 2 diabetes.Methods: Demographic, anthropometric, laboratory data, and arterial stiffness measures including pulse wave velocity (PWV) and augmentation index (AIx) were collected in a cross‐sectional study of 215 adolescents (average age 18 yr) with type 2 diabetes (55% African‐American and 65% female).Results: Compared to Caucasians, African‐Americans had increased PWV (6.21 ± 0.87 vs. 6.96 ± 1.30, p < .01) and AIx (4.44 ± 11.17 vs. 7.64 ± 12.02, p = 0.05). Regression modeling demonstrated age, lipids, blood pressure, and duration of diabetes were differently associated with arterial stiffness in each race group (p < 0.05).Conclusions: African‐American adolescents and young adults with type 2 diabetes have increased vascular stiffness than age‐matched Caucasians. This process is mediated by different cardiovascular risk factors. These results suggest race‐specific risk factor modification may be helpful to prevent early cardiovascular disease in this high risk population.
