Cutting edge:: Memory CD8 T cell maturation occurs independently of CD8αα
Cutting edge:: Memory CD8 T cell maturation occurs independently of CD8αα
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DOI：
10.4049/jimmunol.175.9.5619
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发表时间：
2005-11-01
影响因子：
4.4
通讯作者：
Kaech, SM
中科院分区：
文献类型：
--
作者：
Chandele, A;Kaech, SM
随着记忆 CD8 T 细胞在急性病毒感染过程中形成，基因表达和功能会发生一些变化，但人们对这一过程的控制知之甚少。此前有报道称，同型二聚体CD8αα参与产生IL-7Rα（高）记忆CD8T细胞前体，因此，在CD8aa表达显着受损的动物（E8（I）（-/-）小鼠）中，保护性记忆CD8T细胞不会形成。然而，CD8 α α 对持续 IL-7R α 表达和其他记忆 CD8 T 细胞相关变化的精确贡献尚未得到研究。我们发现，在 E8(I)(-/-) 动物中，IL-7Ra 的表达和记忆 CD8 T 细胞的生成相当正常，以防止继发性病毒感染。有趣的是，与野生型动物相比，E8I(-/-) 小鼠的病毒特异性 CD4 T 细胞反应升高，活化 T 细胞中 CD8 α β 的相对表面水平降低。我们的结果表明记忆 CD8 T 细胞的发育可以独立于 CD8 α α 发生。
As memory CD8 T cells form during acute viral infection, several changes in gene expression and function occur, but little is known about the control of this process. It was reported previously that the homodimer CD8 alpha alpha was involved in generating IL-7R alpha(high) memory CD8 T cell precursors, and consequently, protective memory CD8 T cells did not form in animals significantly impaired in CD8aa expression (E8(I)(-/-) mice). However, the precise contribution of CD8 alpha alpha to sustained IL-7R alpha expression and other memory CD8 T cell-associated changes has not been investigated. We found that IL-7Ra expression and generation of memory CD8 T cells that protect against secondary viral infection was considerably normal in E8(I)(-/-) animals. Interestingly, virus-specific CD4 T cell responses were elevated, and the relative surface levels of CD8 alpha beta in activated T cells were reduced in E8I(-/-) mice compared with wild-type animals. Our results indicate that memory CD8 T cell development can occur independently of CD8 alpha alpha.