Environment matters: microglia function and dysfunction in a changing world.
Environment matters: microglia function and dysfunction in a changing world.
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DOI：
10.1016/j.conb.2017.10.007
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发表时间：
2017-12
影响因子：
5.7
通讯作者：
Bilbo SD
中科院分区：
文献类型：
--
作者：
Hanamsagar R;Bilbo SD
免疫系统是我们与环境的接口，细胞因子和趋化因子等免疫分子以及大脑内产生它们的细胞，特别是小胶质细胞，对正常的大脑发育至关重要。近年来，这种认识导致了一种工作假说，即妊娠或出生后早期的炎症事件，如对感染的反应，可能会扰乱小胶质细胞的正常发育轨迹，从而破坏它们与神经元的相互作用，从而增加神经疾病的风险。目前的文章概述了除感染以外的各种普遍环境挑战的影响，包括空气污染和母体压力；以及它们对小胶质细胞发育的影响及其对神经病理学的广泛影响的最新发现。
The immune system is our interface with the environment, and immune molecules such as cytokines and chemokines and the cells that produce them within the brain, notably microglia, are critical for normal brain development. This recognition has in recent years led to the working hypothesis that inflammatory events during pregnancy or the early postnatal period, e.g. in response to infection, may disrupt the normal developmental trajectory of microglia and consequently their interactions with neurons, thereby contributing to the risk for neurological disorders. The current article outlines recent findings on the impact of diverse, pervasive environmental challenges, beyond infection, including air pollution and maternal stress; and their impact on microglial development and its broad implications for neural pathologies.
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影响因子：
2.7
作者：
Bilbo, SD;Rudy, JW;Maier, SF
通讯作者：
Maier, SF
影响因子：
15.1
作者：
Bland, Sondra T.;Beckley, Jacob T.;Bilbo, Staci D.
通讯作者：
Bilbo, Staci D.
影响因子：
15.1
作者：
Bolton, Jessica L.;Auten, Richard L.;Bilbo, Staci D.
通讯作者：
Bilbo, Staci D.
影响因子：
5.3
作者：
Bilbo, SD;Biedenkapp, JC;Maier, SF
通讯作者：
Maier, SF
影响因子：
15.1
作者：
Delpech, Jean-Christophe;Wei, Lan;Hao, Jin;Yu, Xiaoqing;Madore, Charlotte;Butovsky, Oleg;Kaffman, Arie
通讯作者：
Kaffman, Arie