Promoting Thermodynamically Unfavorable [3,3] Rearrangements by Chemoselective Reduction
Promoting Thermodynamically Unfavorable [3,3] Rearrangements by Chemoselective Reduction
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DOI：
10.1021/acs.orglett.9b02057
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发表时间：
2019-07-19
期刊：
影响因子：
5.2
通讯作者：
Grenning, Alexander J.
中科院分区：
文献类型：
--
作者：
Vertesaljai, Peter;Serrano, Roberto;Grenning, Alexander J.
本文描述的是促进免疫学上不利的[3，3]科普重排的策略。可在还原条件下促进耐热重排的3，3-二氰基-1，5-二烯。还原型科普产品是多功能、双功能的构建模块。
Herein described is a strategy for promoting thermodynamically unfavorable [3,3] Cope rearrangements. 3,3-Dicyano-1,5-dienes that are resistant to the thermal rearrangement can be promoted under reductive conditions. The reduced Cope products are versatile, bifunctional building blocks.