Alcohol consumption and renal cell cancer risk in two Italian case-control studies
Alcohol consumption and renal cell cancer risk in two Italian case-control studies
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DOI：
10.1093/annonc/mdm590
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发表时间：
2008-05-01
影响因子：
50.5
通讯作者：
La Vecchia, C.
中科院分区：
文献类型：
--
作者：
Pelucchi, C.;Galeone, C.;La Vecchia, C.
背景资料：有一些证据表明，酒精消费与肾细胞癌（RCC）呈负相关，但问题仍然不清楚。患者和方法：我们调查的关系使用的数据从两个意大利多中心的病例对照研究进行了1985年至2004年，包括共1115事件，组织学确诊的病例和2582对照住院急性，非肿瘤性条件。结果：与不饮酒者相比，每天饮酒4 - 8杯的RCC的多变量比值比（OR）为0.87 [95%置信区间（CI）0.73-1.04]，风险呈显著的反向趋势（P值= 0.01）。与戒酒者相比，葡萄酒、啤酒和烈酒的OR分别为0.85（95%CI 0.71-1.02）、0.84（95%CI 0.68-1.03）和0.86（95%CI 0.70-1.05）。肾细胞癌的风险没有出现与持续时间（P值= 0.94）和年龄在开始饮酒（P值= 0.81）的趋势。结果是一致的，在男性和女性，以及在年龄，吸烟和身体质量index.Conclusions：这个汇总分析发现饮酒和RCC之间呈负相关。即使每天饮酒超过8杯（即> 100克/天），风险也会继续下降，风险没有明显的水平。
Background: There is some evidence that alcohol consumption is inversely associated with renal cell cancer (RCC), but the issue is still unclear.Patients and methods: We investigated the relation using data from two Italian multicentric case-control studies conducted from 1985 to 2004, including a total of 1115 incident, histologically confirmed cases and 2582 controls hospitalised with acute, non-neoplastic conditions.Results: Compared with non-drinkers, the multivariate odds ratios (ORs) of RCC were 0.87 [95% confidence interval (CI) 0.73-1.04] for 4 to 8 drinks per day of alcoholic beverages, with a significant inverse trend in risk (P value = 0.01). The ORs were 0.85 (95% CI 0.71-1.02) for wine, 0.84 (95% CI 0.68-1.03) for beer and 0.86 (95% CI 0.70-1.05) for spirits consumption, as compared with abstainers. No trend in risk of RCC emerged with duration (P value = 0.94) and age at starting alcohol consumption (P value = 0.81). Results were consistent in men and women, as well as in strata of age, smoking and body mass index.Conclusions: This pooled analysis found an inverse association between alcohol drinking and RCC. Risks continued to decrease even above eight drinks per day (i.e. > 100 g/day) of alcohol intake, with no apparent levelling in risk.