Uncovering the role of genomic "dark matter" in human disease
Uncovering the role of genomic "dark matter" in human disease
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DOI：
10.1172/jci60020
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发表时间：
2012-05-01
影响因子：
15.9
通讯作者：
Chang, Howard Y.
中科院分区：
文献类型：
--
作者：
Martin, Lance;Chang, Howard Y.
人类基因组编码数千个长的非编码RNA(IncRNAs)。尽管大多数IncRNAs仍然没有功能上的特征，但IncRNAs在人类生物学中的不同角色已经引起了相当大的关注，包括发育计划和肿瘤抑制基因网络。随着与人类疾病相关的IncRNAs数量的增加，正在进行的研究工作集中在它们的调控机制上。能够计数IncRNA相互作用伙伴和确定IncRNA结构的新技术很好地推动了对其功能和参与发病机制的更深层次的了解。反过来，lncRNA可能成为治疗干预的目标或生物技术的新工具。
The human genome encodes thousands of long noncociing RNAs (IncRNAs). Although most remain functionally uncharacterized biological "dark matter," IncRNAs have garnered considerable attention for their diverse roles in human biology, including developmental programs and tumor suppressor gene networks. As the number of IncRNAs associated with human disease grows, ongoing research efforts are focusing on their regulatory mechanisms. New technologies that enable enumeration of IncRNA interaction partners and determination of lncRNA structure are well positioned to drive deeper understanding of their functions and involvement in pathogenesis. In turn, lncRNAs may become targets for therapeutic intervention or new tools for biotechnology.