Neurogenesis in the adult hippocampus
Neurogenesis in the adult hippocampus
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DOI：
10.1002/0470870834.ch14
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
Kempermann, G;Gage, FH
令人惊讶的发现是，成年海马体在一生中都会产生新的神经元，这挑战了许多关于大脑的旧观点，因为大脑似乎有足够的可塑性来整合新的神经元。对成年海马神经发生的研究也使人们能够研究成熟和工作大脑中的神经干细胞或祖细胞。因此，它将为任何尝试原位使用神经干细胞治疗神经系统疾病提供必要的关键信息。尽管这一新战略前景广阔，但仍有大量问题有待解决，其中一些问题将在本文中讨论。
The surprising finding that the adult hippocampus produces new neurons throughout life has challenged many old views about the brain, because the brain appears to be plastic enough to integrate new neurons. Research on adult hippocampal neurogenesis also allows one to study neuronal stem or progenitor cells in the mature and working brain. It therefore will provide key information necessary for any attempt to use neuronal stem cells in situ to treat neurological disease. Although this new strategy holds great promise, a large number of questions, some of which are discussed herein, remain to be addressed.