New Insights into the Regulation of Heterochromatin.
New Insights into the Regulation of Heterochromatin.
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对异染色质调节的新见解。
DOI：
10.1016/j.tig.2016.02.005
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Jia S
中科院分区：
文献类型：
--
作者：
Wang J;Jia ST;Jia S
所有生物体都不断地暴露于来自内部生物过程和周围环境的压力，这引起细胞生理学和基因表达程序的许多适应性变化。出乎意料的是，通常与基因沉默的稳定维持相关的组成型异染色质也响应于刺激而动态调节。在这篇综述中，我们将讨论组成性异染色质组装的机制，其动态性质，以及它对环境变化的反应。
All living organisms are constantly exposed to stresses from internal biological processes and surrounding environments, which induce many adaptive changes in cellular physiology and gene expression programs. Unexpectedly, constitutive heterochromatin, which is generally associated with the stable maintenance of gene silencing, is also dynamically regulated in response to stimuli. In this review we will discuss the mechanism of constitutive heterochromatin assembly, its dynamic nature, and its responses to environmental changes.