Localization of Early-Stage Visual Processing Deficits at Schizophrenia Spectrum Illness Onset Using Magnetoencephalography.
Localization of Early-Stage Visual Processing Deficits at Schizophrenia Spectrum Illness Onset Using Magnetoencephalography.
复制标题
使用脑磁图定位精神分裂症谱系疾病发作的早期视觉处理缺陷。
DOI：
10.1093/schbul/sbaa010
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发表时间：
2020
影响因子：
6.6
通讯作者：
Salisbury,DeanF
中科院分区：
文献类型：
--
作者：
Sklar,AlfredoL;Coffman,BrianA;Salisbury,DeanF
在慢性精神病中观察到早期视觉处理的损伤。然而，它们的存在、在脑内的定位以及对认知症状的贡献在疾病过程的早期仍然不太确定。本研究利用脑磁图（MEG）检查初级视皮层（V1）的感觉反应。MEG记录了38个人诊断为精神分裂症谱系疾病在第一次精神病发作（FESz）和38个匹配的健康对照（HC）在视觉搜索任务。推导了M100视觉诱发场皮层活动的逆解。比较两组之间的任务表现和V1激活。相对于HC，FESz表现出降低的V1反应。然而，这组缺陷是选择性的左半球（LH）。观察到类似的相互作用的响应时间与FESz表现出较慢的反应，右视野的目标，HC之间没有观察到的差异。在FESz中，较大的LH V1活性与阳性症状评估量表上较大的幻觉子量表评分相关。在精神分裂症谱系中，在疾病发作时存在定位于V1的早期视觉处理缺陷。这种损害似乎仅限于LH，与先前详细描述早期精神病中主要LH疾病过程的报告一致，并且该区域内的活动与幻觉经验增加相关。这些发现详细说明了导致视觉处理障碍的皮层反应及其与疾病发作时症状的关系，促进了我们对精神疾病过程中其发展轨迹的理解。
Impairments in early-stage visual processing are observed in chronic psychosis. However, their presence, localization within the brain, and contribution to cognitive symptoms remain less well established early in disease course. The present study utilized magnetoencephalography (MEG) to examine sensory responses within primary visual cortex (V1). MEG was recorded from 38 individuals diagnosed with a schizophrenia spectrum illness at first psychotic episode (FESz) and 38 matched healthy controls (HC) during visual search tasks. The inverse solution for cortical activity contributing to the M100 visual evoked field was derived. Task performance and V1 activation were compared between groups. FESz exhibited a reduced V1 response relative to HC. This group deficit, however, was selective for the left hemisphere (LH). A similar interaction was observed for response time with FESz exhibiting slower responses to right visual field targets, a difference not observed among HC. Among FESz, larger LH V1 activity was associated with larger hallucination subscale scores on the Scale for the Assessment of Positive Symptoms. Early-stage visual processing deficits localized to V1 are present at disease onset in the schizophrenia spectrum. This impairment appears to be restricted to the LH, consistent with previous reports detailing a predominantly LH disease process in early psychosis, and activity within this region was associated with an increased experience of hallucinations. These findings detail the cortical responses contributing to visual processing impairments and their relationship with symptoms at disease onset, advancing our understanding of their developmental trajectory over the course of psychotic illness.