The exceptional glutathione peroxidase-like activity of di(3-hydroxypropyl) selenide and the unexpected role of a novel spirodioxaselenanonane intermediate in the catalytic cycle
The exceptional glutathione peroxidase-like activity of di(3-hydroxypropyl) selenide and the unexpected role of a novel spirodioxaselenanonane intermediate in the catalytic cycle
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DOI：
10.1002/anie.200353128
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发表时间：
2004-01-01
影响因子：
16.6
通讯作者：
Parvez, M
中科院分区：
文献类型：
--
作者：
Back, TG;Moussa, Z;Parvez, M
减少氧化应激的新机制：二（3-羟丙基）硒化物在用苄硫醇还原叔丁基氢过氧化物时具有极高的谷胱甘肽过氧化物酶样催化活性。催化循环通过一种新型螺二氧硒壬烷进行，该物质通过光谱和 X 射线晶体学进行了分离和表征。
A new mechanism for reducing oxidative stress: Di (3-hydroxypropyl) selenide has exceptionally high glutathione peroxidase-like catalytic activity in the reduction of tert-butyl hydroperoxide with benzyl thiol. The catalytic cycle proceeds via a novel spirodioxaselenanonane, which was isolated and characterized spectroscopically, as well as by X-ray crystallography.