AN IMMUNOPEROXIDASE STUDY OF S-100 PROTEIN DISTRIBUTION IN NORMAL AND NEOPLASTIC TISSUES
AN IMMUNOPEROXIDASE STUDY OF S-100 PROTEIN DISTRIBUTION IN NORMAL AND NEOPLASTIC TISSUES
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DOI：
10.1097/00000478-198212000-00003
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发表时间：
1982-01-01
影响因子：
5.6
通讯作者：
SHIMOSATO, Y
中科院分区：
文献类型：
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作者：
NAKAJIMA, T;WATANABE, S;SHIMOSATO, Y
在许多类型的福尔马林固定和石蜡包埋的[人]肿瘤（260 例）中对 S-100 蛋白的存在进行了免疫组织化学研究。周围神经肿瘤，即神经鞘瘤、神经纤维瘤、颗粒细胞瘤和神经源性肉瘤，被证明在肿瘤细胞的细胞质和细胞核中含有不同数量的 S-100 蛋白。在神经节神经瘤和神经节神经母细胞瘤中，肿瘤性雪旺细胞或卫星细胞呈 S-100 蛋白阳性。大约 1/2 的类癌病例的 S-100 蛋白染色较弱。除了这些神经组织和类癌肿瘤外，软骨肉瘤、脊索瘤、唾液腺多形性腺瘤和朗格汉斯细胞肉芽肿病也被证明可产生 S-100 蛋白。在许多类型的乳腺肿瘤和其他病变中，S-100蛋白阳性细胞很可能与肌上皮细胞的分布相对应。 S-100 蛋白对于神经组织及其肿瘤并不严格具有特异性；然而，S-100 蛋白的免疫组织化学证明可以成为肿瘤诊断的有用工具。
The presence of S-100 protein was immunohistochemically studied in many types of formalin-fixed and paraffin-embedded [human] tumors (260 cases). Peripheral nerve tumors, i.e., schwannomas, neurofibromas, granular cell tumors and neurogenic sarcomas were demonstrated to contain variable amounts of S-100 protein in the tumor cell cytoplasm and nuclei. In ganglioneuromas and ganglioneuroblastomas, neoplastic Schwann cells or satellite cells were positive for S-100 protein. About 1/2 of the cases of carcinoid tumors stained weakly for S-100 protein. In addition to these nervous tissue and carcinoid tumors, chondrosarcoma, chordomas, pleomorphic adenomas of the salivary gland, and Langerhans cell granulomatosis were also shown to produce S-100 protein. In many types of breast tumors and other lesions, S-100 protein positive cells were likely to correspond to the distribution of myoepithelial cells. S-100 protein is not strictly specific to nervous tissue and its tumors; however, the immunohistochemical demonstration of S-100 protein can be a useful tool in tumor diagnosis.