Prenatal infectious and nutritional factors and risk of adult schizophrenia.
Prenatal infectious and nutritional factors and risk of adult schizophrenia.
复制标题
DOI：
10.1586/14737175.7.7.797
复制
发表时间：
2007-07-01
影响因子：
4.3
通讯作者：
Brown, Alan S
中科院分区：
文献类型：
--
作者：
Penner, Justin D;Brown, Alan S
精神分裂症是一种严重致残的精神疾病。尽管对这种疾病的基础进行了大量的研究，但其病因和发病机制仍然未知。子宫内暴露，包括感染和营养不良，是精神分裂症的重要危险因素，其中神经发育影响可能发挥重要作用。我们的团队和其他人已经开始调查，旨在识别这些风险因素并检查它们增加对这种疾病的易感性的机制。这项工作有可能导致旨在预防这种疾病的策略，并揭示药物干预的新分子靶点。
Schizophrenia is a severely disabling psychiatric disorder. Despite a considerable amount of research on the underpinnings of the disorder, its etiology and pathogenesis remain unknown. In utero exposures, including infection and nutritional deficiencies, are emerging important risk factors for schizophrenia, in which neurodevelopmental influences probably play an important role. Our group and others have embarked on investigations aimed at identifying these risk factors and examining the mechanisms by which they increase vulnerability to this disorder. This work has the potential to lead to strategies aimed at preventing this disorder and to reveal new molecular targets for pharmacotherapeutic intervention.