Brain-derived neurotrophic factor in the infralimbic cortex alleviates inflammatory pain.
Brain-derived neurotrophic factor in the infralimbic cortex alleviates inflammatory pain.
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边缘下皮质中的脑源性神经营养因子可减轻炎性疼痛
DOI：
10.1016/j.neulet.2017.06.028
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发表时间：
2017
影响因子：
2.5
通讯作者：
Wan You
中科院分区：
文献类型：
--
作者：
Yue Lu-Peng;Ma Long-Yu;Cui Shuang;Liu Feng-Yu;Yi Ming;Wan You
在慢性疼痛中，内侧前额叶皮层（mPFC）起着重要的调节作用，并可能在功能和形态上发生改变。脑源性神经营养因子（BDNF）是中枢神经系统神经元兴奋性和突触传递的重要调节因子。本研究的目的是探讨BDNF在完全弗氏佐剂（CFA）诱导的炎性疼痛中mPFC边缘下皮层和边缘前皮层的作用。我们发现，在CFA诱导炎症性疼痛后3天，边缘下皮层的BDNF水平降低，但在边缘前皮层中没有。脑源性神经营养因子注入双侧边缘下皮层激活神经元活动可以缓解炎症性疼痛，加速疼痛的长期恢复。总之，mPFC边缘下皮层的BDNF可以加速炎症性疼痛的恢复。
In chronic pain, it has been reported that the medial prefrontal cortex (mPFC) takes important regulatory roles, and may change functionally and morphologically in result of chronic pain. Brain-derived neurotrophic factor (BDNF) is well known as a critical modulator of neuronal excitability and synaptic transmission in the central nervous system. The aim of the present study is to investigate the role of BDNF in the infralimbic cortex and the prelimbic cortex of the mPFC in complete Freund’s adjuvant (CFA)-induced inflammatory pain. We found that the BDNF level decreased in the infralimbic cortex, but not in the prelimbic cortex, 3 days after the CFA induction of the inflammatory pain. BDNF infusion into bilateral infralimbic cortices to activate neuronal activities could alleviate inflammatory pain and accelerate long-term recovery from pain. In conclusion, BDNF in the infralimbic cortex of the mPFC could accelerate recovery from inflammatory pain.