Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women.
Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women.
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中国绝经后女性血清GDF11水平与骨密度及骨转换标志物的关系
DOI：
10.1038/boneres.2016.12
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发表时间：
2016
期刊：
影响因子：
12.7
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Chen Y;Guo Q;Zhang M;Song S;Quan T;Zhao T;Li H;Guo L;Jiang T;Wang G
生长分化因子11 （Growth differentiation factor 11, GDF11）是调节衰老的重要循环因子。然而，GDF11在骨代谢中的作用尚不清楚。本研究旨在探讨绝经后中国妇女血清GDF11水平、骨量和骨转换标志物之间的关系。测定了169例47 ~ 78岁绝经后中国妇女血清GDF11水平、骨转换生化指标及骨密度（BMD）。血清GDF11水平随年龄增长而升高。不同骨骼部位的GDF11与骨密度呈负相关。在调整了年龄和身体质量指数（BMI）后，相关性仍然具有统计学意义。在多元线性逐步回归分析中，年龄或绝经年数、BMI、GDF11和雌二醇是BMD的独立预测因子。GDF11与骨碱性磷酸酶（BAP）呈显著负相关，在调整年龄和BMI后仍然显著。I型胶原交联n端肽（NTX）与GDF11之间无显著相关性。总之，GDF11是绝经后中国妇女骨密度的独立阴性预测因子，并与骨形成的生物标志物BAP相关。GDF11可能通过调节骨形成对骨量产生负面影响。
Growth differentiation factor 11 (GDF11) is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density (BMD) were determined in 169 postmenopausal Chinese women (47–78 years old). GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index (BMI), the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase (BAP) was identified and remained significant after adjusting for age and BMI. No significant correlation was noted between cross-linked N-telopeptides of type I collagen (NTX) and GDF11. In conclusion, GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation, BAP, in postmenopausal Chinese women. GDF11 potentially exerts a negative effect on bone mass by regulating bone formation.