Process Development of Halaven®: Synthesis of the C14-C35 Fragment via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization
Process Development of Halaven®: Synthesis of the C14-C35 Fragment via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization
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DOI：
10.1055/s-0032-1317920
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发表时间：
2013-02-01
期刊：
影响因子：
2
通讯作者：
Yoshizawab, Kazuhiro
中科院分区：
文献类型：
--
作者：
Austad, Brian C.;Benayoud, Farid;Yoshizawab, Kazuhiro
描述了Halaven（R）C14-C35片段的数公斤制造过程。该合成的特点是通过在固定设备中执行的迭代不对称Ni/Cr介导的偶联进行亚基的会聚组装。
Multikilogram manufacturing process of the Halaven (R) C14-C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.