Tabernaesine J, a Novel Vincamine‐Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic‐Ring System Scaffold from Tabernaemontana pachysiphon
Tabernaesine J, a Novel Vincamine‐Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic‐Ring System Scaffold from Tabernaemontana pachysiphon
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Tabernaesine J，一种来自 Tabernaemontana pchysiphon 的新型长春胺型吲哚生物碱，具有 6/5/6/6/6/5/5 七环环系统支架
DOI：
10.1002/cjoc.202100634
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发表时间：
2021-11
影响因子：
5.4
通讯作者：
Xiao‐Jiang Hao
中科院分区：
文献类型：
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作者：
Wen‐Fang Yi;Tiwalade A. Adelakun;Xue Bai;Yu Zhang;Xiao‐Jiang Hao
Tabernaesine J（1）是一个前所未有的具有6/5/6/6/6/5/5七环系统的长春胺型吲哚生物碱，以及一个新的生物遗传学相关的长春胺型吲哚生物碱（2），从Tabernaemontana pachysiphon的叶子中分离得到。其结构通过HRESIMS、NMR、单晶X射线衍射和ECD计算的组合确定。假设他本奈辛J（1）中前所未有的五内酯环衍生自乙酰辅酶A烯醇化阴离子。生物碱2与氟康唑联合应用有可能克服白念珠菌对氟康唑的耐药性。
Comprehensive SummaryTabernaesine J (1), an unprecedented vincamine‐type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic‐ring system, as well as one new biogenetically related vincamine‐type indole alkaloid (2), were isolated from leaves ofTabernaemontana pachysiphon. Their structures were established by a combination of HRESIMS, NMR, single crystal X‐ray diffraction, and ECD calculation. The unprecedented penta‐lactone ring in tabernaesine J (1) was postulated to be derived from acetyl‐CoA enolate anion. Alkaloid 2 combined with fluconazole has the potential to overcome fluconazole resistance inCandida albicans.