RADIATION DOSE-RESPONSE OF HUMAN TUMORS
RADIATION DOSE-RESPONSE OF HUMAN TUMORS
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DOI：
10.1016/0360-3016(94)00475-z
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发表时间：
1995-07-15
影响因子：
7
通讯作者：
SUIT, HD
中科院分区：
文献类型：
--
作者：
OKUNIEFF, P;MORGAN, D;SUIT, HD
目的：局部控制选择性治疗或总体疾病的人类肿瘤的辐射剂量很少得到很好的定义，这些剂量可以用于理解具有非均匀剂量学和辅助设置的新疗法的剂量要求，本研究的目标是计算局部控制人类受试者50%肿瘤的辐射剂量（TCD50）。方法和材料：对从单个机构收集的数据或从多个治疗同一疾病的机构收集的当地对照数据进行合法回归。结果：计算出90条剂量反应曲线；总体疾病的TCD50平均值和中位数分别为50.0和51.9 Gy，微观疾病控制的TCD50平均值和中位数分别为39.3和37.9 Gy，在TCD50水平上，每增加1 Gy的剂量，宏观疾病患者的额外控制率为2.5%（中位数），微观疾病患者的额外控制率为4.2%（中位数）。在TCD50下，剂量每增加1%，控制率就增加约1%（中位数）或2-3%（平均值）。大多数剂量反应曲线斜率较浅，导致平均值和中位数之间存在差异。结论：控制微观疾病的剂量比控制宏观疾病所需的剂量少约12 Gy，约为控制宏观疾病所需剂量的79%，剂量每增加1%，宏观疾病和微观疾病的预期治愈率增加百分比相似，中位数约为1%/%，平均值约为2.7%/%。
Purpose: The dose of radiation that locally controls human tumors treated electively or for gross disease is rarely well defined, These doses can be useful in understanding the dose requirements of novel therapies featuring inhomogeneous dosimetry and in an adjuvant setting, The goal of this study was to compute the dose of radiation that locally controls 50% (TCD50) of tumors in human subjects.Methods and Materials: Legit regression was used with data collected from single institutions or from combinations of local control data accumulated from several institutions treating the same disease.Results: 90 dose response curves were calculated; 62 of macroscopic tumor therapy, 28 of elective therapy with surgery for primary control, The mean and median TCD50 for gross disease were 50.0 and 51.9 Gy, respectively, The mean and median TCD50 for microscopic disease control were 39.3 and 37.9 Gy, respectively, At the TCD50 an additional dose of 1 Gy controlled an additional 2.5 % (median) additional patients with macroscopic disease and 4.2% (median) additional patients with microscopic disease, For both macro-and microscopic disease, an increase of 1% of dose at the TCD50 increased control rates approximate to 1% (median) or 2-3% (mean), A predominance of dose response curves had shallow slopes accounting for the discrepancy between mean and median values.Conclusion: Doses to control microscopic disease are approximately 12 Gy less than that required to control macroscopic disease, and are about 79 % of the dose required to control macroscopic disease, The percentage increase in cures expected for a 1% increase in dose is similar for macroscopic and microscopic disease, with a median value of approximate to 1%/% and a mean of approximate to 2.7%/%.