Suppression of enriched environment-induced neurogenesis in a rodent model of neuropathic pain
Suppression of enriched environment-induced neurogenesis in a rodent model of neuropathic pain
复制标题
DOI：
10.1016/j.neulet.2008.05.078
复制
发表时间：
2008-08
影响因子：
2.5
通讯作者：
Mioko Terada;N. Kuzumaki;Nana Hareyama;S. Imai;K. Niikura;Michiko Narita;M. Yamazaki;Tsutomu Suzuki;M. Narita
中科院分区：
文献类型：
--
作者：
Mioko Terada;N. Kuzumaki;Nana Hareyama;S. Imai;K. Niikura;Michiko Narita;M. Yamazaki;Tsutomu Suzuki;M. Narita
暴露于丰富的环境（EE）增强神经发生和调节情绪。以前的报道已经揭示了神经发生的速率可以受到各种环境、内分泌和药理学刺激的影响。慢性疼痛是一种使人衰弱的疾病状态，其特征在于外周和中枢伤害性通路的复杂改变。在本研究中，我们评估了慢性疼痛对环境富集诱导的海马神经发生的影响。将神经结扎的小鼠圈养在标准环境或EE中4周。EE增加了齿状回（DG）中未成熟神经元阳性细胞的标记物双皮质素（DCX）的免疫反应性。此外，NeuroD（神经源性基本螺旋环螺旋因子）阳性细胞的数量，在DG中明显增加EE。在这些条件下，慢性疼痛抑制丰富的环境介导的诱导DCX和NeuroD标记的细胞。这些结果表明，慢性疼痛对海马神经发生具有应激样损伤调节作用。
Exposure to an enriched environment (EE) enhances neurogenesis and regulates emotionality. Previous reports have revealed that the rate of neurogenesis can be influenced by various environmental, endocrine, and pharmacologic stimuli. Chronic pain is a debilitating disease state characterized by complex alterations in both peripheral and central nociceptive pathways. In the present study, we evaluated the effect of chronic pain on environmental enrichment-induced hippocampal neurogenesis. Nerve-ligated mice were housed either in a standard environment or in the EE for 4 weeks. EE increased the immunoreactivity for doublecortin (DCX), a marker for immature neuron-positive cells, in the dentate gyrus (DG). Furthermore, the number of NeuroD (a neurogenic basic helix–loop–helix factor)-positive cells, in the DG was clearly increased by EE. Under these conditions, chronic pain suppressed enriched environment-mediated induction of both DCX- and NeuroD-labeled cells. These results suggest that chronic pain has stress-like damaging modulatory effects on hippocampal neurogenesis.