Insulin Resistance: The Possible Link Between Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy
Insulin Resistance: The Possible Link Between Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy
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DOI：
10.1007/s11892-009-0046-1
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发表时间：
2009-08-01
影响因子：
4.2
通讯作者：
Homko, Carol J.
中科院分区：
文献类型：
--
作者：
Mastrogiannis, Dimitrios S.;Spiliopoulos, Michail;Homko, Carol J.
妊娠期高血压、先兆子痫和糖尿病都与母亲和围产儿结局不良的风险增加有关。人群研究表明，与非糖尿病妇女相比，患有妊娠期糖尿病的孕妇患妊娠高血压的风险更高。此外，患有高血压的孕妇患妊娠期糖尿病的风险更高。据推测，这种联系可能至少部分归因于胰岛素抵抗。虽然胰岛素抵抗是正常妊娠的一种生理现象，但在易患妊娠高血压综合征和/或妊娠期糖尿病的个体中，胰岛素抵抗可能会导致高胰岛素血症。
Gestational hypertension, preeclampsia, and diabetes are all associated with increased risks of poor maternal and perinatal outcomes. Pregnant women with gestational diabetes have been shown in population studies to have increased risk of pregnancy-associated hypertension compared with nondiabetic women. Moreover, pregnant patients with hypertension are at increased risk for developing gestational diabetes mellitus. It has been hypothesized that this association could be due, at least in part, to insulin resistance. Although insulin resistance is a physiologic phenomenon in normal pregnancy, in predisposed individuals this could lead to hyperinsulinemia with the development of gestational hypertension, gestational diabetes mellitus, or both.